Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.

Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.
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线粒体转移是一种新型的疾病诊断和治疗治疗方法。

DOI:
10.3390/ijms24108848
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发表时间:
2023-05-16
影响因子:
5.6
通讯作者:
--
中科院分区:
生物学2区
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--
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线粒体功能障碍是许多疾病的标志,包括神经退行性疾病、代谢疾病和癌症。线粒体转移,即线粒体从一个细胞转移到另一个细胞,最近已成为恢复病变细胞中线粒体功能的潜在治疗方法。在这篇综述中,我们总结了目前对线粒体转移的理解,包括其机制,潜在的治疗应用,以及对细胞死亡途径的影响。我们还讨论了线粒体转移作为疾病诊断和治疗的新治疗方法领域的未来方向和挑战。
Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.
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