Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules.
Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules.
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DOI：
10.1039/c4cs00280f
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发表时间：
2015-07-07
影响因子：
46.2
通讯作者：
Sessler JL
中科院分区：
文献类型：
--
作者：
Lee MH;Kim JS;Sessler JL
特定分析物的定量测定对于从生命科学到环境监测的各种应用至关重要。光学感测允许生物环境内的非侵入性测量、多个样本的并行监测以及侵入性较小的成像。在目前正在探索的光学传感方法中，比率荧光传感作为一种有可能提供精确和定量分析的技术受到了特别的关注。其优点包括高灵敏度和固有的可靠性，这反映了通过监测两个（或多个）排放提供的自校准。已经开发了各种各样的使用小荧光分子的比率传感探针用于传感、成像和生物医学应用。在这项研究的亮点，我们提供了一个概述的设计原则，已被应用到各种分析物，包括阳离子，阴离子和生物分子的比例检测的小荧光探针在溶液中和生物样品。这一重点是为了说明，而不是全面的。
Quantitative determination of specific analytes is essential for a variety of applications ranging from life sciences to environmental monitoring. Optical sensing allows non-invasive measurements within biological milieus, parallel monitoring of multiple samples, and less invasive imaging. Among the optical sensing methods currently being explored, ratiometric fluorescence sensing has received particular attention as a technique with the potential to provide precise and quantitative analyses. Among its advantages are high sensitivity and inherent reliability, which reflect the self-calibration provided by monitoring two (or more) emissions. A wide variety of ratiometric sensing probes using small fluorescent molecules have been developed for sensing, imaging, and biomedical applications. In this research highlight, we provide an overview of the design principles underlying small fluorescent probes that have been applied to the ratiometric detection of various analytes, including cations, anions, and biomolecules in solution and in biological samples. This highlight is designed to be illustrative, not comprehensive.
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朝着炎症性疾病的化学标志物：一种荧光探针，用于膜定位的硫氧还蛋白。
影响因子：
15
作者：
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