The role of structural genomic variants in population differentiation and ecotype formation in Timema cristinae walking sticks
The role of structural genomic variants in population differentiation and ecotype formation in Timema cristinae walking sticks
复制标题
结构基因组变异在 Timema cristinae 手杖种群分化和生态型形成中的作用
DOI：
10.1111/mec.15016
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发表时间：
2019
影响因子：
4.9
通讯作者：
Nosil, Patrik
中科院分区：
文献类型：
--
作者：
Lucek, Kay;Gompert, Zachariah;Nosil, Patrik
理论预测，结构基因组变异，如倒位，可以促进适应性多样化和物种形成。尽管有越来越多的经验证据表明，适应性分化可以由一个或几个大的倒位触发，在何种程度上广泛的基因组区域在不同的选择与结构变异仍不清楚。在这里，我们测试结构变异和基因组区域之间的关联，这些区域是平行宿主植物相关生态型形成的基础。通过对20个新的全基因组进行配对重测序，我们发现中等大小的结构变异，如倒位、缺失和重复，在整个基因组中广泛存在，并作为种群内和种群间的常设变异保留下来。使用160个先前发表的标准方向全基因组序列，我们发现几乎没有证据表明倒位内的DNA序列表现出生态型之间的突出差异。相比之下，先前描述的含有控制颜色模式的基因的减少重组的大区域表现出生态类型之间突出分化的证据，这与宿主相关生态类型之间颜色模式变体频率的差异一致。我们的研究结果表明，某些类型的结构变异（例如，大倒位）比其他倒位更有可能成为适应性分化的基础，并且结构变异对于具有基因流的微妙但全基因组遗传分化并不是必需的。
Theory predicts that structural genomic variants such as inversions can promote adaptive diversification and speciation. Despite increasing empirical evidence that adaptive divergence can be triggered by one or a few large inversions, the degree to which widespread genomic regions under divergent selection are associated with structural variants remains unclear. Here we test for an association between structural variants and genomic regions that underlie parallel host‐plant‐associated ecotype formation inTimema cristinaestick insects. Using mate‐pair resequencing of 20 new whole genomes we find that moderately sized structural variants such as inversions, deletions and duplications are widespread across the genome, being retained as standing variation within and among populations. Using 160 previously published, standard‐orientation whole genome sequences we find little to no evidence that the DNA sequences within inversions exhibit accentuated differentiation between ecotypes. In contrast, a formerly described large region of reduced recombination that harbours genes controlling colour‐pattern exhibits evidence for accentuated differentiation between ecotypes, which is consistent with differences in the frequency of colour‐pattern morphs between host‐associated ecotypes. Our results suggest that some types of structural variants (e.g., large inversions) are more likely to underlie adaptive divergence than others, and that structural variants are not required for subtle yet genome‐wide genetic differentiation with gene flow.
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影响因子：
3.7
作者：
Fan S;Meyer A
通讯作者：
Meyer A
影响因子：
56.9
作者：
Nosil, Patrik;Villoutreix, Romain;Gompert, Zach
通讯作者：
Gompert, Zach
DOI：
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发表时间：
--
期刊：
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影响因子：
--
作者：
通讯作者：
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影响因子：
7
作者：
McKenna, Aaron;Hanna, Matthew;DePristo, Mark A.
通讯作者：
DePristo, Mark A.
影响因子：
5
作者：
Lundberg M;Liedvogel M;Larson K;Sigeman H;Grahn M;Wright A;Åkesson S;Bensch S
通讯作者：
Bensch S