Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin.
Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin.
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DOI：
10.3390/biom13030513
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发表时间：
2023-03-10
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
TRPV3是一种非选择性阳离子通道，在皮肤角质形成细胞中高度表达。传统上，角质形成细胞表达的TRPV3参与皮肤的多种生理和病理功能，如瘙痒、热痛和毛发发育。虽然TRPV3在体内发挥作用的潜在机制仍然不清楚，但最近的研究表明可能涉及几种细胞因子和EGFR信号通路。然而，也有其他研究提出了相反的结果，质疑TRPV3在热痛中的作用。此外，越来越多的研究表明TRPV3在促进皮肤再生中的新作用，表明TRPV3可能成为调节皮肤再生的新的潜在靶点。本文综述了角质形成细胞表达的TRPV3在瘙痒、热痛、毛发发育和皮肤再生等生理病理过程中的作用，以及TRPV3基因突变与特应性皮炎（AD）和Olmsted综合征（OS）等皮肤疾病的关系。本文的综述将为进一步了解TRPV3参与瘙痒、热痛和毛发发育的机制以及TRPV3相关皮肤病的治疗奠定基础。
TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair development. Although the underlying mechanisms by which TRPV3 functions in vivo remain obscure, recent research studies suggest that several cytokines and EGFR signaling pathways may be involved. However, there have also been other studies with opposite results that question the role of TRPV3 in heat pain. In addition, an increasing number of studies have suggested a novel role of TRPV3 in promoting skin regeneration, indicating that TRPV3 may become a new potential target for regulating skin regeneration. This paper not only reviews the role of keratinocytes-expressed TRPV3 in the physiological and pathological processes of itching, heat pain, hair development, and skin regeneration, but also reviews the relationship between TRPV3 gene mutations and skin diseases such as atopic dermatitis (AD) and Olmsted syndrome (OS). This review will lay a foundation for further developing our understanding of the mechanisms by which TRPV3 is involved in itching, heat pain, and hair development, as well as the treatments for TRPV3-related skin diseases.
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影响因子：
6.5
作者：
Borbiro, Istvan;Lisztes, Erika;Biro, Tamas
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
The Journal of general physiology
影响因子：
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通讯作者：
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2005-03-08
期刊：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2007.08.170
发表时间：
2007-11-23
影响因子：
3.1
作者：
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通讯作者：
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