SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy.
SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapy.
复制标题
基于 SmartArc 的子宫内膜癌体积调制弧疗法：与螺旋断层放射治疗和强度调制放射治疗的剂量学比较。
DOI：
10.1186/1471-2407-13-515
复制
发表时间：
2013-11-01
期刊：
影响因子：
3.8
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Yang R;Wang J;Xu S;Li H
本研究的目的是探讨在治疗子宫内膜癌时，使用SmartArc（VMAT-S）的体积调强弧治疗（VMAT-S）实现高于调强放疗（IMRT）和螺旋断层放疗（HT）的辐射输送效率的可行性，同时保持计划质量。对9例子宫内膜癌患者进行回顾性研究。每例患者生成VMAT-S、IMRT和HT的三个计划。比较了计划靶区（PTV）、危及器官（OAR）和正常组织的剂量分布。还评价了监测单位（MU）和治疗输送时间。VMAT-S、IMRT和HT计划的平均均匀性指数分别为1.06、1.10和1.07。与IMRT计划相比，VMAT-S计划中直肠、膀胱和骨盆骨的V40分别降低了9.0%、3.0%和3.0%。VMAT-S和HT计划的目标覆盖率和OAR的保留率相当。VMAT-S、IMRT和HT的平均MU分别为823、1105和8403;平均输送时间分别为2.6、8.6和9.5分钟。对于子宫内膜癌，VMAT-S计划提供了可比的质量，与IMRT和HT计划相比，交付时间明显缩短，MU减少。此外，相对于调强放射治疗计划，在VMAT-S中观察到中高剂量区域中PTV覆盖更均匀，OAR保留上级。
The purpose of the present study was to investigate the feasibility of using volumetric modulated arc therapy with SmartArc (VMAT-S) to achieve radiation delivery efficiency higher than that of intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) when treating endometrial cancer, while maintaining plan quality. Nine patients with endometrial cancer were retrospectively studied. Three plans per patient were generated for VMAT-S, IMRT and HT. The dose distributions for the planning target volume (PTV), organs at risk (OARs) and normal tissue were compared. The monitor units (MUs) and treatment delivery time were also evaluated. The average homogeneity index was 1.06, 1.10 and 1.07 for the VMAT-S, IMRT and HT plans, respectively. The V40 for the rectum, bladder and pelvis bone decreased by 9.0%, 3.0% and 3.0%, respectively, in the VMAT-S plan relative to the IMRT plan. The target coverage and sparing of OARs were comparable between the VMAT-S and HT plans. The average MU was 823, 1105 and 8403 for VMAT-S, IMRT and HT, respectively; the average delivery time was 2.6, 8.6 and 9.5 minutes, respectively. For endometrial cancer, the VMAT-S plan provided comparable quality with significantly shorter delivery time and fewer MUs than with the IMRT and HT plans. In addition, more homogeneous PTV coverage and superior sparing of OARs in the medium to high dose region were observed in the VMAT-S relative to the IMRT plan.
登录
查看更多内容
影响因子：
120.7
作者：
Baxter, NN;Habermann, EB;Virnig, BA
通讯作者：
Virnig, BA
影响因子：
5.7
作者：
Cozzi, Luca;Dinshaw, Ketayun Ardeshir;Fogliata, Antonella
通讯作者：
Fogliata, Antonella
影响因子：
5.7
作者：
Clivio, Alessandro;Fogliata, Antonella;Cozzi, Luca
通讯作者：
Cozzi, Luca
DOI：
10.1016/s0360-3016(01)02785-7
发表时间：
2002-04-01
影响因子：
7
作者：
Mundt, AJ;Lujan, AE;Roeske, JC
通讯作者：
Roeske, JC
影响因子：
5.7
作者：
Vanetti, Eugenio;Clivio, Alessandro;Cozzi, Luca
通讯作者：
Cozzi, Luca