Prenatal acoustic programming of mitochondrial function for high temperatures in an arid-adapted bird.
Prenatal acoustic programming of mitochondrial function for high temperatures in an arid-adapted bird.
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DOI：
10.1098/rspb.2021.1893
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发表时间：
2021-12-08
期刊：
影响因子：
--
通讯作者：
Mariette MM
中科院分区：
文献类型：
--
作者：
Udino E;George JM;McKenzie M;Pessato A;Crino OL;Buchanan KL;Mariette MM
声音是许多类群中重要的信息来源，尤其可以被胚胎用来为出生后环境编程其表型。虽然基本机制大多未知，但越来越多的证据表明线粒体（细胞能量（即 ATP）的主要来源）参与发育编程过程。在这里，我们测试了产前声音是否会影响线粒体代谢。对于适应干旱的斑胸草雀来说，产前接触由父母在高温下孵化时发出的“热叫声”会适应性地改变雏鸟在高温下的生长。我们测量了产前暴露于热或控制信号并在对比热环境中饲养的雏鸟的红细胞线粒体功能。暴露在高温下总是会降低线粒体 ATP 的生产效率。然而，正如预期的减少热量产生的那样，产前接触热呼叫可以提高温和热条件下的线粒体效率。此外，当暴露于急性热挑战时，热呼叫雏鸟的泄漏呼吸较高，并且在不同温度下线粒体效率较低。与其减少氧化损伤的作用一致，在快速生长的雏鸟中，极端高温下的泄漏也较高。因此，我们的研究首次证明了线粒体声敏感性，并使我们更接近于了解声学发育编程和鸟类热适应策略的基础。
Sound is an essential source of information in many taxa and can notably be used by embryos to programme their phenotypes for postnatal environments. While underlying mechanisms are mostly unknown, there is growing evidence for the involvement of mitochondria—main source of cellular energy (i.e. ATP)—in developmental programming processes. Here, we tested whether prenatal sound programmes mitochondrial metabolism. In the arid-adapted zebra finch, prenatal exposure to ‘heat-calls’—produced by parents incubating at high temperatures—adaptively alters nestling growth in the heat. We measured red blood cell mitochondrial function, in nestlings exposed prenatally to heat- or control-calls, and reared in contrasting thermal environments. Exposure to high temperatures always reduced mitochondrial ATP production efficiency. However, as expected to reduce heat production, prenatal exposure to heat-calls improved mitochondrial efficiency under mild heat conditions. In addition, when exposed to an acute heat-challenge, LEAK respiration was higher in heat-call nestlings, and mitochondrial efficiency low across temperatures. Consistent with its role in reducing oxidative damage, LEAK under extreme heat was also higher in fast growing nestlings. Our study therefore provides the first demonstration of mitochondrial acoustic sensitivity, and brings us closer to understanding the underpinning of acoustic developmental programming and avian strategies for heat adaptation.
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发表时间：
2019-04-15
影响因子：
6.3
作者：
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影响因子：
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通讯作者：
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