Motility and chemotaxis in Campylobacter and Helicobacter .

Motility and chemotaxis in Campylobacter and Helicobacter .
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DOI:
10.1146/annurev-micro-090110-102908
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发表时间:
2011
影响因子:
10.5
通讯作者:
Hendrixson DR
Hendrixson DR
中科院分区:
生物学1区
文献类型:
--
作者:
Lertsethtakarn P;Ottemann KM;Hendrixson DR

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空肠弯曲菌和幽门螺杆菌的鞭毛运动通过促进穿过粘性环境(例如胃肠道粘液)的迁移来影响宿主定殖。本综述探讨了C. jejuni和H. pylori用来控制鞭毛生物合成和趋化反应。这些微生物严格控制σ54和σ28的活性以介导鞭毛基因的有序表达。除了相位可变和翻译后机制,鞭毛生物合成的空间和数字调节,使只有一定数量的细胞器被放置在极性网站。为了介导趋化性,C. jejuni和H. pylori联合收割机将基本的趋化性信号转导成分与几种辅助蛋白结合。H. pylori的不寻常之处在于它缺乏基于甲基化的适应系统并产生多种Chev偶联蛋白。这些细菌中的化学感受器含有非保守的配体结合域,其中几种化学感受器与环境信号相匹配。总之,这些机制允许游泳运动,这是必不可少的殖民。
Flagellar motility of Campylobacter jejuni and Helicobacter pylori influences host colonization by promoting migration through viscous milieus such as gastrointestinal mucus. This review explores mechanisms C. jejuni and H. pylori employ to control flagellar biosynthesis and chemotactic responses. These microbes tightly control the activities of σ54 and σ28 to mediate ordered flagellar gene expression. In addition to phase-variable and posttranslational mechanisms, flagellar biosynthesis is regulated spatially and numerically so that only a certain number of organelles are placed at polar sites. To mediate chemotaxis, C. jejuni and H. pylori combine basic chemotaxis signal transduction components with several accessory proteins. H. pylori is unusual in that it lacks a methylation-based adaptation system and produces multiple CheV coupling proteins. Chemoreceptors in these bacteria contain nonconserved ligand binding domains, with several chemoreceptors matched to environmental signals. Together, these mechanisms allow for swimming motility that is essential for colonization.
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