Altered microRNA expression following traumatic spinal cord injury.
Altered microRNA expression following traumatic spinal cord injury.
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创伤性脊髓损伤后的microRNA表达改变。
DOI：
10.1016/j.expneurol.2009.06.015
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发表时间：
2009-10
影响因子：
5.3
通讯作者：
Xu, Xiao-Ming
中科院分区：
文献类型：
--
作者：
Liu, Nai-Kui;Wang, Xiao-Fei;Lu, Qing-Bo;Xu, Xiao-Ming
MicroRNAs （miRNAs）是一类新型的小非编码rna，通过与靶mrna的3 '非翻译区结合，在转录后水平负调控基因表达，导致其翻译抑制或有时降解。我们利用微阵列分析发现，在成年大鼠的挫伤脊髓损伤（SCI）后，大量mirna的时间表达发生了以前未知的变化。这些改变的mirna可分为三类：(1)上调，(2)下调，(3)sci后4小时早期上调，随后在1天和7天下调。生物信息学分析表明，脊髓损伤后发生改变的mirna的潜在靶标包括编码参与炎症、氧化和凋亡的基因，这些基因在脊髓损伤的发病机制中起重要作用。这些发现表明，mirna的异常表达可能与脊髓损伤的发病机制有关，是脊髓损伤后治疗干预的潜在靶点。
MicroRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the posttranscriptional level by binding to the 3’ untranslated region of target mRNAs leading to their translational inhibition or sometimes degradation. We uncovered a previously unknown alteration in temporal expression of a large set of miRNAs following a contusive spinal cord injury (SCI) in adult rats using microarray analysis. These altered miRNAs can be classified into 3 categories: (1) up-regulation, (2) down-regulation and (3) an early up-regulation at 4 hours followed by down-regulation at 1 and 7 days post-SCI. The bioinformatics analysis indicates that the potential targets for miRNAs altered after SCI include genes encoding components that are involved in the inflammation, oxidation, and apoptosis that are known to play important roles in the pathogenesis of SCI. These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI.
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影响因子：
56.9
作者：
Kim, Jongpil;Inoue, Keiichi;Abeliovich, Asa
通讯作者：
Abeliovich, Asa
影响因子：
82.9
作者：
Crowe, MJ;Bresnahan, JC;Beattie, MS
通讯作者：
Beattie, MS
影响因子：
4.2
作者：
Nesic, O;Svrakic, NM;Perez-Polo, JR
通讯作者：
Perez-Polo, JR
影响因子：
11.2
作者：
Liu, NK;Zhang, YP;Xu, XM
通讯作者：
Xu, XM
DOI：
10.1073/pnas.2333854100
发表时间：
2004-01-06
影响因子：
11.1
作者：
Kim, J;Krichevsky, A;Ruvkun, G
通讯作者：
Ruvkun, G