The National Cardiovascular Center Electrohydraulic Total Artificial Heart and Ventricular Assist Device Systems: Current Status of Development
The National Cardiovascular Center Electrohydraulic Total Artificial Heart and Ventricular Assist Device Systems: Current Status of Development
复制标题
国家心血管中心电液全人工心脏和心室辅助装置系统：发展现状
DOI：
10.1097/01.mat.0000065374.83106.fe
复制
发表时间：
2003
期刊：
影响因子：
4.2
通讯作者：
Hideaki Yamaguchi
中科院分区：
文献类型：
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作者：
E. Tatsumi;Y. Taenaka;A. Homma;T. Nishinaka;Y. Takewa;T. Tsukiya;H. Ohnishi;M. Oshikawa;Y. Shirakawa;Y. Kakuta;K. Shioya;N. Katagiri;T. Mizuno;T. Kamimura;H. Takano;K. Tsukahara;K. Tsuchimoto;H. Wakui;Hideaki Yamaguchi
电液式全人工心脏（EHTAH）和电液式心室辅助装置（EHVAD）是我所研制成功的。EHTAH系统包括由血泵和致动器组成的泵送装置，以及由内部控制器、内部和外部电池组成的电子装置，以及经皮能量传输（泰特）和光学遥测（TOT）子单元。置于心包腔外的致动器往复运动，并通过一对柔性油导管将液压硅油输送至备用血泵。将带有外部控制器的泵送装置植入10头小至55 kg的小牛体内。两只动物存活超过12周，一般状况良好。假设心输出量范围为6 - 10 L/min，功耗为12-18 W，能量效率估计为9- 11%。在另一头体重73 kg的小牛中进一步进行了包括电子装置的次全系统的初始植入。它存活了3天，完全无系绳系统。EHVAD系统是通过使用EHTAH的左血泵和致动器开发的，它们被包装在具有顺应性腔室的紧凑金属外壳中。体外试验表明，最大输出超过9 L/min，最大效率超过13%。最初的动物试验持续了25天。这些结果表明，我们的EHTAH和EHVAD有潜力成为完全植入式系统。
Electrohydraulic total artificial heart (EHTAH) and electrohydraulic ventricular assist device (EHVAD) systems have been developed in our institute. The EHTAH system comprises a pumping unit consisting of blood pumps and an actuator, as well as an electronic unit consisting of an internal controller, internal and external batteries, and transcutaneous energy transfer (TET) and optical telemetry (TOT) subunits. The actuator, placed outside the pericardial space, reciprocates and delivers hydraulic silicone oil to the alternate blood pumps through a pair of flexible oil conduits. The pumping unit with an external controller was implanted in 10 calves as small as 55 kg. Two animals survived for more than 12 weeks in a good general condition. The assumed cardiac output ranged between 6 and 10 L/min, the power consumption was 12–18 W, and the energy efficiency was estimated to be 9–11%. Initial implantation of subtotal system including electronic units was further conducted in another calf weighing 73 kg. It survived for 3 days with a completely tether free system. The EHVAD system is developed by using the left blood pump and the actuator of the EHTAH, which were packaged in a compact metal casing with a compliance chamber. In vitro testing demonstrated maximum output more than 9 L/min and more than 13% maximum efficiency. The initial animal testing lasted for 25 days. These results indicate that our EHTAH and EHVAD have the potential to be totally implantable systems.
DOI：
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发表时间：
1993
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
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作者：
Tatsumi,E;Khanwilkar,PS;Rowles,JR;Chiang,BY;Burns,GL;Long,JW;Hansen,AC;Holfert,JW;Bearnson,GB;Crump,KR
通讯作者：
Crump,KR
带有心房分流器的血泵，用作电动液压全人工心脏。
DOI：
10.1097/00002480-199207000-00069
发表时间：
1992
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Tatsumi,E;Diegel,PD;Holfert,JW;Dew,PA;Crump,KR;Hansen,AC;Khanwilkar,PS;Rowles,JR;Olsen,DB
通讯作者：
Olsen,DB
完全植入的全人工心脏系统的体内测试。
DOI：
--
发表时间：
1993
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Snyder,AJ;Rosenberg,G;Weiss,WJ;Ford,SK;Nazarian,RA;Hicks,DL;Marlotte,JA;Kawaguchi,O;Prophet,GA;Sapirstein,JS
通讯作者：
Sapirstein,JS