Validation of Diagnosis Codes to Identify Infection-Related Acute Care Events in Patients With Glomerular Disease.
Validation of Diagnosis Codes to Identify Infection-Related Acute Care Events in Patients With Glomerular Disease.
复制标题
DOI：
10.1016/j.ekir.2021.08.019
复制
发表时间：
2021-12
影响因子：
6
通讯作者：
CureGN Consortium
中科院分区：
文献类型：
--
作者：
Glenn DA;Zee J;Hegde A;Henderson C;O'Shaughnessy MM;Bomback A;Gibson K;Greenbaum LA;Mansfield S;Hu Y;Mariani L;Falk R;Hogan S;Denburg M;Mottl A;CureGN Consortium
在美国，肾小球疾病占慢性肾脏疾病(CKD)的7%至16%，影响260万至600万美国人。1肾小球疾病患者有感染并发症的独特危险因素，包括长期接触免疫抑制药物、全身炎症、免疫细胞功能改变以及尿免疫球蛋白和补体因子丢失。因此，患有肾小球疾病的人的感染率大约是普通美国人的30倍。3干预性研究通常收集和报告不良感染事件的数据，这对于了解患者的福祉和治疗方案的相对安全性至关重要。然而，发生在现实世界临床环境中的传染病事件研究得较少。准确识别临床实践中发生的感染事件可能是一项艰巨的任务，因为这些事件的记录嵌入到电子医疗记录(EMR)或医疗保健索赔数据中。临床医生和编码员分配的诊断代码很容易搜索，但由于时间障碍、人为错误和诊断编码的复杂性，往往是有缺陷的。涉及手动审查医疗记录的裁决是黄金标准方法，但耗费大量人力和时间。在这里，我们开发了一种基于诊断代码−的算法，然后测试其内部有效性，以在CureGN研究中的大量儿童和成人肾小球疾病患者中识别与感染相关的急性护理事件。CureGN是一项前瞻性、多中心、观察性队列研究，研究对象为经活检证实的肾小球疾病患者，包括微小病变疾病、局灶性节段性肾小球硬化、膜性肾病或免疫球蛋白A肾病/血管炎。参与者来自美国、加拿大、意大利和波兰的72个临床地点。使用面对面或远程访问，每6个月收集并更新临床数据，包括任何间隔急诊室访问或住院的详细信息。CureGN研究的详细方法之前已经发表过。4.
Glomerular diseases comprise 7% to 16% of chronic kidney disease (CKD) in the United States, affecting between 2.6 and 6 million Americans. 1 Individuals with glomerular disease have unique risk factors for infectious complications, including prolonged exposure to immunosuppressive medications, systemic inflammation, altered immune cell function, and urinary loss of immunoglobulin and complement factors. 2 As a result, individuals with glomerular disease experience rates of infection that are approximately 30 times higher than those of the general US population. 3 Interventional studies typically collect and report data on adverse infectious events, which is critical to understanding patient well-being and the relative safety of therapeutic options. However, infectious events occurring in real-world clinical settings are less well studied. Accurate identification of infectious events occurring in clinical practice can be an arduous task, as recording of these events is embedded in electronic medical records (EMRs) or healthcare claims data. Diagnosis codes assigned by clinicians and coders are easily searchable but are often flawed because of time barriers, human error, and the complexities of diagnostic coding. Adjudication involving manual review of medical records is the gold standard approach but is labor and time intensive. Herein, we have developed a diagnosis code− based algorithm and then tested its internal validity to identify infection-related acute care events within a large cohort of children and adults with glomerular disease in the CureGN study.CureGN is a prospective, multicenter, observational cohort study of patients with biopsy-proven glomerular disease, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy/vasculitis. Participants are enrolled from 72 clinical sites in the United States, Canada, Italy, and Poland. Using in-person or remote visits, clinical data are collected and updated every 6 months, including details of any interval emergency room visits or hospitalizations. Detailed methods for the CureGN study have been previously published. 4
登录
查看更多内容
影响因子：
2.6
作者：
Sahli, Line;Lapeyre-Mestre, Maryse;Moulis, Guillaume
通讯作者：
Moulis, Guillaume
DOI：
10.2215/cjn.05900420
发表时间：
2020-12-07
影响因子：
9.8
作者：
Glenn, Dorey A.;Henderson, Candace D.;Mottl, Amy
通讯作者：
Mottl, Amy
DOI：
10.1007/s00467-015-3241-0
发表时间：
2016-09
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
McCaffrey J;Lennon R;Webb NJ
通讯作者：
Webb NJ
影响因子：
4.7
作者：
Barber, Claire;Lacaille, Diane;Fortin, Paul R.
通讯作者：
Fortin, Paul R.
影响因子：
1.5
作者：
Gillespie BW;Laurin LP;Zinsser D;Lafayette R;Marasa M;Wenderfer SE;Vento S;Poulton C;Barisoni L;Zee J;Helmuth M;Lugani F;Kamel M;Hill-Callahan P;Hewitt SM;Mariani LH;Smoyer WE;Greenbaum LA;Gipson DS;Robinson BM;Gharavi AG;Guay-Woodford LM;Trachtman H
通讯作者：
Trachtman H