A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language.

A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language.
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DOI:
10.1186/gb-2011-12-1-r8
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发表时间:
2011
期刊:
影响因子:
12.3
通讯作者:
Shevchenko A
Shevchenko A
中科院分区:
生物学1区
文献类型:
--
作者:
Herzog R;Schwudke D;Schuhmann K;Sampaio JL;Bornstein SR;Schroeder M;Shevchenko A

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Shotgun lipidome profiling relies on direct mass spectrometric analysis of total lipid extracts from cells, tissues or organisms and is a powerful tool to elucidate the molecular composition of lipidomes. We present a novel informatics concept of the molecular fragmentation query language implemented within the LipidXplorer open source software kit that supports accurate quantification of individual species of any ionizable lipid class in shotgun spectra acquired on any mass spectrometry platform.
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