Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection.
Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection.
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慢性丙型肝炎病毒感染患者的细胞免疫效应器功能、铁代谢和疾病活动之间的关联。
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
V. R. Gordeuk
中科院分区：
文献类型：
--
作者：
Günter Weiss;F. Umlauft;Martina Urbanek;Manfred Herold;Mark Lovevsky;F. Offner;V. R. Gordeuk
We studied the associations of macrophage activity, T-helper cell types 1 and 2 (Th-1/Th-2) responses, and iron status in 55 patients with hepatitis C virus (HCV)-related liver disease and 28 control patients with noninfectious liver disease. Serum concentrations of soluble tumor necrosis factor receptor type II (sTNFrec 75), a macrophage activation marker, were higher in cirrhotic than in noncirrhotic patients (P<.001) regardless of their HCV status, whereas levels of neopterin, interleukin (IL)-4 and IL-10 did not differ significantly. In HCV-positive patients, sTNFrec 75 levels and transferrin saturation (TfS) correlated positively with levels of aspartate transaminase (P<.001 for sTNFrec 75 and P=.028 for TfS) and alanine transaminase (P=.003 for sTNFrec 75 and P=.039 for TfS). Increased TfS correlated significantly with both advanced liver disease and a predominant Th-2 pattern in HCV patients. Our data suggest that an association exists between macrophage activation and hepatic dysfunction, and that iron status may affect the clinical course of HCV infection by modulating Th-1/Th-2 responses in vivo.
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影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
影响因子：
56.9
作者：
KARUPIAH, G;XIE, QW;MACMICKING, JD
通讯作者：
MACMICKING, JD
人肝细胞中诱导型一氧化氮合酶的分子克隆和表达
DOI：
10.1073/pnas.90.8.3491
发表时间：
1993-04-15
影响因子：
11.1
作者：
GELLER, DA;LOWENSTEIN, CJ;BILLIAR, TR
通讯作者：
BILLIAR, TR
影响因子：
56.9
作者：
XIE, QW;CHO, HJ;NATHAN, C
通讯作者：
NATHAN, C
影响因子：
158.5
作者：
GORDEUK, V;THUMA, P;POLTERA, AA
通讯作者：
POLTERA, AA