Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study
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rTMS 治疗难治性抑郁症引起的脑脊液代谢物变化：一项初步研究

DOI：
10.1016/j.psychres.2022.114636
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发表时间：
2022
期刊：
Psychiatry Research
影响因子：
11.3
通讯作者：
Monji Akira
Monji Akira
中科院分区：
医学2区
文献类型：
--
作者：
Tateishi Hiroshi;Setoyama Daiki;Kato Takahiro A;Kang Dongchon;Matsushima Jun;Nogami Kojiro;Mawatari Seiji;Kojima Ryohei;Fujii Yuka;Sakemura Yuta;Shiraishi Takumi;Imamura Yoshiomi;Maekawa Toshihiko;Asami Toyoko;Mizoguchi Yoshito;Monji Akira

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重复经颅磁刺激（rTMS）可改善难治性抑郁症（TRD）的抑郁症状。本研究旨在分析rTMS后TRD患者脑脊液（CSF）代谢物的变化。5例TRD患者入组高频（10 Hz）rTMS研究。在基线和6周rTMS治疗结束时测量72种CSF代谢物的浓度。rTMS显著增加了CSF烟酰胺、犬尿氨酸和肌酐水平，显著降低了CSF胱氨酸水平，但未降低其他68种CSF代谢物的水平。这是对接受rTMS的TRD患者进行的第一项CSF代谢组学研究。
Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.
Human plasma metabolites predict severity of depression
人类血浆代谢物预测抑郁症的严重程度
DOI： --
发表时间： 2015
期刊：
影响因子： --
作者：
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Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study
DOI： 10.1016/j.psychres.2020.112995
发表时间： 2020-04
期刊： Psychiatry Research
影响因子： 11.3
作者：
H. Tateishi;Y. Mizoguchi;A. Kawaguchi;Yoshiomi Imamura;Jun Matsushima;H. Kunitake;Toru Murakawa;Y. Haraguchi;Yutaka Kunitake;T. Maekawa;Takahiro A. Kato;T. Asami;A. Monji
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重复经颅磁刺激治疗抑郁症：前景广阔，但仍有很多问题
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发表时间： 2009
期刊： Brain Stimulation
影响因子： 7.7
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发表时间： 2005-04-01
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Ihara, Y;Takata, H;Hayabara, T
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