Correlations of dual-energy X-ray absorptiometry, quantitative computed tomography, and single photon absorptiometry with spinal and non-spinal fractures
Correlations of dual-energy X-ray absorptiometry, quantitative computed tomography, and single photon absorptiometry with spinal and non-spinal fractures
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双能 X 射线吸收测定法、定量计算机断层扫描和单光子吸收测定法与脊柱和非脊柱骨折的相关性
DOI：
10.1007/bf01623015
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发表时间：
2005
影响因子：
4
通讯作者：
D. Rowland
中科院分区：
文献类型：
--
作者：
F. Lafferty;D. Rowland
关于哪种测量骨矿物质密度（BMD）的方法最能检测骨质疏松症，并与脊柱、髋关节和其他部位的骨折最相关，仍存在争议。为了回答这些问题，我们在90名受试者中仔细确定了骨折的患病率采用脊柱计算机断层扫描（QCT）、脊柱前后位（AP）和仰卧侧位双能X线吸收法（DXA）、股骨颈和全髋DXA、以及远端第三桡骨DXA和单光子吸收测定法（SPA）。在检测骨质疏松症（定义为30岁时BMD低于峰值骨量的-2.5 SD）方面，DXA测量的灵敏度最高的是仰卧侧位脊柱DXA（84%）和股骨颈DXA（75%）;灵敏度较低的是桡骨远端三分之一（61%）和AP脊柱（51%）的DXA测量。在检测轻度原发性甲状旁腺功能亢进的骨质减少方面，股骨颈和桡骨远端三分之一的DXA测量比脊柱测量更有用。椎体压缩性骨折（VCF）与脊柱QCT（r=-0.38）和脊柱侧位DXA（r=-0.41）相关性良好，但与AP脊柱DXA（r=-0.17）和远端第三桡骨DXA（r=-0.02）相关性较差。非脊柱骨折与远端第三桡骨DXA相关性最好（r=-0.42）。结论：脊柱QCT、仰卧位DXA和股骨颈DXA是筛查60岁以上女性骨质疏松症的最佳BMD方法，而AP脊柱DXA是一种较差的筛查方法。脊柱QCT和脊柱侧位DXA与VCF相关性良好，而VCF与AP脊柱DXA、股骨颈DXA和远端第三桡骨DXA的相关性较差。
Controversy continues as to which method of measuring bone mineral density (BMD) best detects osteoporosis and best correlates with fractures of the spine, hip and elsewhere. To answer these questions the prevalence of fractures was carefully determined among 90 subjects (70 with osteoporosis, 6 with mild primary hyperparathyroidism, 1 with osteomalacia and 13 normals) and simultaneous measurements were made using spinal computed tomography (QCT), spinal anteroposterior (AP) and supine lateral dual X-ray absorptiometry (DXA), femoral neck and total hip DXA, and distal third radial DXA and single photon absorptiometry (SPA). The DXA measurements which had the greatest sensitivity in detecting osteoporosis (defined as a BMD lower than −2.5 SD of peak bone mass at age 30 years) were the supine lateral spine DXA (84%) and femoral neck DXA (75%); less sensitive were the DXA measurements of the distal third of the radius (61%) and AP spine (51%). DXA measurements of the femoral neck and distal third of the radius were more useful than spinal measurements in detecting the osteopenia of mild primary hyperparathyroidism. Vertebral compression fractures (VCF) correlated well with spinal QCT (r=−0.38) and lateral spine DXA (r=−0.41), but poorly with AP spine DXA (r=−0.17) and distal third radial DXA (r=−0.02). Non-spinal fractures correlated best with the distal third radial DXA (r=−0.42). In conclusion, spinal QCT, supine lateral spine DXA and femoral neck DXA are the best BMD methods to screen for osteoporosis, whereas AP spine DXA is a poor screening method in women over 60 years of age. Spinal QCT and lateral spine DXA correlate well with VCFs, whereas correlations of VCFs with AP spine DXA, femoral neck DXA and distal third radial DXA are poor.
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影响因子：
4.1
作者：
CANN, CE;GENANT, HK;ETTINGER, B
通讯作者：
ETTINGER, B
侧向与前后脊柱双能 X 射线吸收测量法诊断骨质减少的比较。
DOI：
10.1210/jcem.78.3.8126149
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Finkelstein,JS;Cleary,RL;Butler,JP;Antonelli,R;Mitlak,BH;Deraska,DJ;Zamora-Quezada,JC;Neer,RM
通讯作者：
Neer,RM
未经治疗的原发性甲状旁腺功能亢进症的骨密度和生化指标的纵向测量。
DOI：
10.1210/jcem.80.3.7883823
发表时间：
1995
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Silverberg,SJ;Gartenberg,F;Jacobs,TP;Shane,E;Siris,E;Staron,RB;Bilezikian,JP
通讯作者：
Bilezikian,JP
影响因子：
15.9
作者：
RIGGS, BL;WAHNER, HW;MELTON, LJ
通讯作者：
MELTON, LJ