Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH).
Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH).
复制标题
胆碱缺乏型 L-氨基酸高脂饮食 (CDAHFD) 诱导的非酒精性脂肪性肝炎 (NASH) 小鼠模型中血清胆固醇和甘油三酯水平降低。
DOI：
10.1248/bpb.b19-00338
复制
发表时间：
2020
影响因子：
2
通讯作者：
N. Kume
中科院分区：
文献类型：
--
作者：
D. Yasuda;Haruki Torii;Rumiko Shimizu;Yoshinori Hiraoka;N. Kume
由于腹部肥胖的增加，非酒精性脂肪肝病（NAFLD）或非酒精性脂肪性肝炎（NASH）是世界范围内的主要健康问题之一。迄今为止，尚未建立治疗或预防 NAFLD/NASH 的特异性且有效的药物。为了确定适当的分子靶标，已探索了合适的 NAFLD/NASH 动物模型。一种缺乏胆碱的氨基酸高脂饮食 (CDAHFD) 诱导的 NASH 小鼠模型已被开发出来。然而，其与人类 NASH（包括血清脂质谱）的相关性尚未明确定义。在这项研究中，我们发现喂食 CDAHFD 的小鼠除了体重 (BW) 降低外，血清总胆固醇和甘油三酯 (TG) 水平也显着降低。此外，CDAHFD 喂养的小鼠肝微粒体甘油三酯转移蛋白 (MTP) 表达显着下调。因此，目前的 CDAHFD 喂养小鼠模型与人类 NAFLD/NASH 不同，一般而言，其基于腹部肥胖。
Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic seatohepatitis (NASH) is one of the major health problems world wide, because of increased abdominal obesity. To date, specific and effective medications to treat or prevent NAFLD/NASH have not been established. To identify appropriate molecular targets for that purpose, suitable animal models of NAFLD/NASH have been explored. A choline-deficient amino acid-defined high fat diet (CDAHFD)-induced mouse model of NASH has been developed. However, its relevance to human NASH, including serum lipid profiles, have not been clearly defined. In this study, we have revealed that mice fed CDAHFD showed significantly lowerd serum total cholesterol and triglyceride (TG) levels, in addition to reduced body weight (BW). Furthermore, hepatic microsomal triglyceride transfer protein (MTP) expression was significantly downregulated in CDAHFD-fed mice. Thus, the current CDAHFD-fed mouse model has points that are distinct from human NAFLD/NASH, in general, which is based upon abdominal obesity.
影响因子：
3.9
作者：
Denda, Ayumi;Kitayama, Wakashi;Kuniyasu, Hiroki
通讯作者：
Kuniyasu, Hiroki