Risks of alcohol and drug use disorders in prostate cancer survivors: a national cohort study.
Risks of alcohol and drug use disorders in prostate cancer survivors: a national cohort study.
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DOI：
10.1093/jncics/pkad046
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发表时间：
2023-07-03
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
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作者：
前列腺癌（PC）幸存者可能会使用药物来科普心理困扰或控制不良的身体症状。然而，对PC男性中酒精使用障碍（AUD）或药物使用障碍的长期风险知之甚少。在瑞典进行了一项全国性队列研究，研究对象为1998年至2017年期间诊断为PC的180189名男性和1801890名年龄匹配的基于人群的对照男性。 AUD和药物使用障碍是从2018年的全国记录中确定的。采用考克斯回归计算风险比（HR），同时调整社会人口因素和既往精神疾病。亚组分析检查了2005年至2017年PC治疗的差异。高风险PC男性的AUD（校正HR = 1.44，95%置信区间[CI] = 1.33 - 1.57）和药物使用障碍（校正HR = 1.93，95% CI = 1.67 - 2.24）风险均增加。他们的AUD风险在第一年最高，在PC诊断后5年不再显著升高，而他们的药物使用障碍风险在PC诊断后10年仍升高（校正HR = 2.26，95% CI = 1.45至3.52），特别是阿片类药物使用障碍（校正HR = 3.07，95% CI = 1.61至5.84）。仅接受雄激素剥夺治疗的患者发生AUD（校正HR = 1.91，95% CI = 1.62 - 2.25）和药物使用障碍（校正HR = 2.23，95% CI = 1.70 - 2.92）的风险最高。低风险或中风险PC与AUD（校正HR = 1.38，95% CI = 1.30 - 1.46）和药物使用障碍（校正HR = 1.19，95% CI = 1.06 - 1.34）风险中度增加相关。在这个大型队列中，PC男性患者的AUD和药物使用障碍的风险显著增加，特别是那些高危PC和仅接受雄激素剥夺治疗的患者。PC幸存者需要长期的心理支持，并及时发现和治疗AUD和药物使用障碍。
Prostate cancer (PC) survivors may potentially use substances to cope with psychological distress or poorly controlled physical symptoms. Little is known, however, about the long-term risks of alcohol use disorder (AUD) or drug use disorders in men with PC. A national cohort study was conducted in Sweden of 180 189 men diagnosed with PC between 1998 and 2017 and 1 801 890 age-matched population-based control men. AUD and drug use disorders were ascertained from nationwide records through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors and prior psychiatric disorders. Subanalyses examined differences by PC treatment from 2005 to 2017. Men with high-risk PC had increased risks of both AUD (adjusted HR = 1.44, 95% confidence interval [CI] = 1.33 to 1.57) and drug use disorders (adjusted HR = 1.93, 95% CI = 1.67 to 2.24). Their AUD risk was highest in the first year and was no longer significantly elevated 5 years after PC diagnosis, whereas their drug use disorders risk remained elevated 10 years after PC diagnosis (adjusted HR = 2.26, 95% CI = 1.45 to 3.52), particularly opioid use disorder (adjusted HR = 3.07, 95% CI = 1.61 to 5.84). Those treated only with androgen-deprivation therapy had the highest risks of AUD (adjusted HR = 1.91, 95% CI = 1.62 to 2.25) and drug use disorders (adjusted HR = 2.23, 95% CI = 1.70 to 2.92). Low- or intermediate-risk PC was associated with modestly increased risks of AUD (adjusted HR = 1.38, 95% CI = 1.30 to 1.46) and drug use disorders (adjusted HR = 1.19, 95% CI = 1.06 to 1.34). In this large cohort, men with PC had significantly increased risks of both AUD and drug use disorders, especially those with high-risk PC and treated only with androgen-deprivation therapy. PC survivors need long-term psychosocial support and timely detection and treatment of AUD and drug use disorders.
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影响因子：
7.2
作者：
Baumeister, H;Balke, K;Härter, M
通讯作者：
Härter, M
DOI：
10.1016/j.urolonc.2014.05.005
发表时间：
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影响因子：
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作者：
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1.3
作者：
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影响因子：
1.1
作者：
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通讯作者：
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DOI：
10.1007/s10552-021-01513-2
发表时间：
2022-03
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Dahlman D;Li X;Crump C;Sundquist J;Sundquist K
通讯作者：
Sundquist K