Drug use disorder and risk of incident and fatal prostate cancer among Swedish men: a nationwide epidemiological study.
Drug use disorder and risk of incident and fatal prostate cancer among Swedish men: a nationwide epidemiological study.
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DOI：
10.1007/s10552-021-01513-2
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发表时间：
2022-03
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影响因子：
--
通讯作者：
Sundquist K
中科院分区：
文献类型：
--
作者：
Dahlman D;Li X;Crump C;Sundquist J;Sundquist K
前列腺癌是男性第二常见的癌症，也是全球癌症死亡率的主要原因。患有药物使用障碍（DUD）的男性可能由于延迟诊断和/或治疗不足而处于前列腺癌死亡率的高风险中。在这项研究中，我们的目的是调查前列腺癌的发病率，死亡率和诊断时的阶段与男性DUD相比，在瑞典的一般男性人口。我们根据1997年1月至2016年12月期间的瑞典国家登记数据进行了随访研究。该研究基于1，361，532名年龄在50-75岁之间的男性，其中9，259名登记为DUD。使用考克斯回归分析来计算与DUD相关的新发和致命前列腺癌以及诊断时癌症分期的调整后风险比（HR）。DUD与前列腺癌发病风险略有增加相关（HR：1.07，95%置信区间[CI] 1.00-1.14，p = 0.048）和致死性前列腺癌风险显著升高（HR：1.59，95% CI 1.40-1.82，p < 0.001），校正了年龄、社会经济因素以及与吸烟和酒精使用障碍相关的合并症。DUD与前列腺癌诊断分期之间无相关性。DUD男性患致命性前列腺癌的风险增加，可能与该患者人群的治疗不足有关。我们的研究结果应该引起医务人员和决策者对弱势群体男性的关注，他们需要方便的前列腺癌评估和治疗。在线版本包含补充材料，可通过10.1007/s10552-021-01513-2获得。
Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs) for incident and fatal prostate cancer, and cancer stage at time of diagnosis, associated with DUD. DUD was associated with a slightly increased risk of incident prostate cancer (HR: 1.07, 95% confidence interval [CI] 1.00–1.14, p = 0.048) and substantially higher risk of fatal prostate cancer (HR: 1.59, 95% CI 1.40–1.82, p < 0.001), adjusted for age, socioeconomic factors, and comorbidities related to tobacco smoking and alcohol use disorder. No association was found between DUD and prostate cancer stage at diagnosis. Men with DUD have an increased risk of fatal prostate cancer, possibly related to undertreatment in this patient population. Our findings should raise attention among medical staff and decision-makers towards a disadvantaged group of men in need of easily accessible prostate cancer evaluation and treatment. The online version contains supplementary material available at 10.1007/s10552-021-01513-2.
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影响因子：
2.1
作者：
Islam, M. M.;Taylor, A.;Day, C. A.
通讯作者：
Day, C. A.
DOI：
10.1111/j.1440-1746.2005.03882.x
发表时间：
2005-07-01
影响因子：
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DOI：
10.1111/j.1749-6632.2011.06202.x
发表时间：
2012-01-01
期刊：
ADDICTION REVIEWS
影响因子：
--
作者：
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通讯作者：
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影响因子：
4.2
作者：
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