Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis.
Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis.
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DOI：
10.1016/j.envres.2017.06.038
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发表时间：
2017-10
影响因子：
8.3
通讯作者：
PILAR Research Network
中科院分区：
文献类型：
--
作者：
Astuti Y;Wardhana A;Watkins J;Wulaningsih W;PILAR Research Network
Cigarette smoking is a risk factor for ageing-related disease, but its association with biological ageing, indicated by telomere length, is unclear. We systematically reviewed evidence evaluating association between smoking status and telomere length. Searches were performed in MEDLINE (Ovid) and EMBASE (Ovid) databases, combining variation of keywords “smoking” and “telomere”. Data was extracted for study characteristics and estimates for association between smoking and telomere length. Quality of studies was assessed with a risk of bias score, and publication bias was assessed with a funnel plot. I2 test was used to observe heterogeneity. Meta-analysis was carried out to compare mean difference in telomere length by smoking status, and a dose-response approach was carried out for pack-years of smoking and telomere length. A sensitivity analysis was carried out to examine sources of heterogeneity. A total of 84 studies were included in the review, and 30 among them were included in our meta-analysis. Potential bias was addressed in half of included studies, and there was little evidence of small study bias. Telomere length was shorter among ever smokers compared to never smokers (summary standard mean difference [SMD]: −0.11 (95% CI −0.16 to −0.07)). Similarly, shorter telomere length was found among smokers compared to non-smokers, and among current smokers compared to never or former smokers. Dose-response meta-analysis suggested an inverse trend between pack-years of smoking and telomere length. However, heterogeneity among some analyses was observed. Shorter telomeres among ever smokers compared to those who never smoked may imply mechanisms linking tobacco smoke exposure to ageing-related disease. Shorter telomere length is a marker for cellular ageing and chronic diseases. We systematically reviewed 84 primary studies on smoking and telomere length. Telomere length was shorter in ever smokers compared to never smokers. Among ever smokers, current smokers had shorter mean telomeres than former smokers. An inverse trend was indicated between pack-years of smoking and telomere length.
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影响因子：
4
作者：
Crippa A;Orsini N
通讯作者：
Orsini N
DOI：
10.1097/jom.0b013e318188b90a
发表时间：
2008-12-01
影响因子：
3.2
作者：
Arheart, Kristopher L.;Lee, David J.;Erard, Michael J.
通讯作者：
Erard, Michael J.
影响因子：
5.2
作者：
Broer, Linda;Codd, Veryan;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
DOI：
10.1126/science.aag0299
发表时间：
2016-11-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Alexandrov LB;Ju YS;Haase K;Van Loo P;Martincorena I;Nik-Zainal S;Totoki Y;Fujimoto A;Nakagawa H;Shibata T;Campbell PJ;Vineis P;Phillips DH;Stratton MR
通讯作者：
Stratton MR
影响因子：
5
作者：
Aviv A;Chen W;Gardner JP;Kimura M;Brimacombe M;Cao X;Srinivasan SR;Berenson GS
通讯作者：
Berenson GS