Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets.
Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets.
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DOI：
10.1016/j.ijid.2004.07.014
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发表时间：
2005-11
期刊：
影响因子：
--
通讯作者：
Dwyer DE
中科院分区：
文献类型：
--
作者：
He Z;Zhao C;Dong Q;Zhuang H;Song S;Peng G;Dwyer DE
严重的急性呼吸道综合征（SARS）在2003年引起了非典型肺炎的大规模暴发，中国北京的局部暴发最大。
在271个SARS冠状病毒感染的个体中检查了SAR对外周血淋巴细胞及其亚群的影响。
CD45+，CD3+，CD4+，CD8+，CD19+和CD16+/56+细胞计数在SARS疾病的五周内显着下降，尽管CD4+/CD8+比率没有显着变化。第7-9天，在疾病的第二周中，五周后恢复正常，平均CD4+细胞计数最低，为317个细胞×106/L，在第7天，在第8天，CD8+细胞计数为239个细胞×106/L。更严重的临床疾病或死亡的患者的CD4+和CD8+淋巴细胞减少症。
淋巴细胞减少是SARS-COV感染的重要部分，淋巴细胞计数可能有助于预测与SARS相关的淋巴细胞的可能原因。 - 介导的淋巴细胞运输也可能存在免疫介导的淋巴细胞破坏，骨髓或胸腺抑制或凋亡。
Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7–9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells × 106/L at day 7, and CD8+ cell count of 239 cells × 106/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.
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影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
DOI：
10.1016/s0140-6736(03)13967-0
发表时间：
2003-07-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Kuiken T;Fouchier RA;Schutten M;Rimmelzwaan GF;van Amerongen G;van Riel D;Laman JD;de Jong T;van Doornum G;Lim W;Ling AE;Chan PK;Tam JS;Zambon MC;Gopal R;Drosten C;van der Werf S;Escriou N;Manuguerra JC;Stöhr K;Peiris JS;Osterhaus AD
通讯作者：
Osterhaus AD
DOI：
10.1016/s0140-6736(03)13364-8
发表时间：
2003-05-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hon KL;Leung CW;Cheng WT;Chan PK;Chu WC;Kwan YW;Li AM;Fong NC;Ng PC;Chiu MC;Li CK;Tam JS;Fok TF
通讯作者：
Fok TF
DOI：
10.1128/cdli.11.4.792-794.2004
发表时间：
2004-07-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
He, ZP;Dong, QM;Dwyer, DE
通讯作者：
Dwyer, DE