Immune Sensing of Candida albicans.
Immune Sensing of Candida albicans.
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DOI：
10.3390/jof7020119
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发表时间：
2021-02-06
期刊：
影响因子：
--
通讯作者：
Hall RA
中科院分区：
文献类型：
--
作者：
Bojang E;Ghuman H;Kumwenda P;Hall RA
白色念珠菌感染范围从浅表到全身，是与真菌相关的医院感染的主要原因之一。这些不同感染类型的先天免疫反应不同，表明宿主环境在调节宿主与病原体的相互作用中起着关键作用。此外，白念珠菌能够根据环境条件重塑细胞壁，以逃避宿主清除机制，并在利基环境中建立感染，如口腔和阴道粘膜。吞噬细胞在清除白色念珠菌中起着关键作用，这主要是通过病原体相关分子模式(PAMP)-模式识别受体(PRR)相互作用来介导的。它们分别与β-葡聚糖、N-甘露聚糖、O-甘露聚糖等PAMP相互作用，激活天然免疫细胞。先天免疫细胞表现出不同但重叠的PAMP谱系，导致它们优先识别特定的念珠菌形态类型。吞噬细胞在不同感染类型中的作用也不同，中性粒细胞在肾脏感染中起重要作用，树突状细胞在皮肤感染中起重要作用。在这篇综述中，我们概述了参与检测白色念珠菌的关键受体，并讨论了在不同的感染类型中对白色念珠菌的不同先天免疫反应，如外阴阴道念珠菌病和口腔念珠菌病。
Candida albicans infections range from superficial to systemic and are one of the leading causes of fungus-associated nosocomial infections. The innate immune responses during these various infection types differ, suggesting that the host environment plays a key role in modulating the host–pathogen interaction. In addition, C. albicans is able to remodel its cell wall in response to environmental conditions to evade host clearance mechanisms and establish infection in niches, such as the oral and vaginal mucosa. Phagocytes play a key role in clearing C. albicans, which is primarily mediated by Pathogen Associated Molecular Pattern (PAMP)–Pattern Recognition Receptor (PRR) interactions. PRRs such as Dectin-1, DC-SIGN, and TLR2 and TLR4 interact with PAMPs such as β-glucans, N-mannan and O-mannan, respectively, to trigger the activation of innate immune cells. Innate immune cells exhibit distinct yet overlapping repertoires of PAMPs, resulting in the preferential recognition of particular Candida morphotypes by them. The role of phagocytes in the context of individual infection types also differs, with neutrophils playing a prominent role in kidney infections, and dendritic cells playing a prominent role in skin infections. In this review, we provide an overview of the key receptors involved in the detection of C. albicans and discuss the differential innate immune responses to C. albicans seen in different infection types such as vulvovaginal candidiasis (VVC) and oral candidiasis.
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DOI：
10.1038/nrm2867
发表时间：
2010-04
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.9
作者：
Bishu S;Su EW;Wilkerson ER;Reckley KA;Jones DM;McGeachy MJ;Gaffen SL;Levesque MC
通讯作者：
Levesque MC
影响因子：
28.3
作者：
Ballou ER;Avelar GM;Childers DS;Mackie J;Bain JM;Wagener J;Kastora SL;Panea MD;Hardison SE;Walker LA;Erwig LP;Munro CA;Gow NA;Brown GD;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
3.3
作者：
Canton J;Khezri R;Glogauer M;Grinstein S
通讯作者：
Grinstein S
影响因子：
1.2
作者：
Ambe, Ngwa Fabrice;Longdoh, Njunda Anna;Cumber, Samuel Nambile
通讯作者：
Cumber, Samuel Nambile