A sexually conditioned switch of chemosensory behavior in C. elegans.
A sexually conditioned switch of chemosensory behavior in C. elegans.
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DOI：
10.1371/journal.pone.0068676
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Iino Y
中科院分区：
文献类型：
--
作者：
Sakai N;Iwata R;Yokoi S;Butcher RA;Clardy J;Tomioka M;Iino Y
在有性繁殖的动物中，交配对于将遗传信息传递给下一代至关重要，因此动物进化出了优化成功交配机会的机制。土壤线虫C.在线虫中，雄性通过蛔虫苷信息素接近雌雄同体，当它们的尾巴接触雌雄同体的身体时识别雌雄同体，并最终与它们交配。这些过程由专门用于性交流的感觉信号介导，但其他机制也可用于优化配偶位置。在这里，我们描述的联想学习，男性使用氯化钠作为线索雌雄同体的位置。雄性和雌雄同体动物在经过盐和饥饿的联合条件反射后，通常都会避免氯化钠。然而，我们发现，男性成为吸引氯化钠后，空调与盐和饥饿，如果雌雄同体是目前在空调。对于这种条件作用，我们称之为性条件作用，雌雄同体是通过信息素信号和额外的线索被雄性发现的。性别转换实验表明，神经元的男性性是必不可少的性条件反射。总之，这些结果表明，C。秀丽线虫雄性综合环境、内部和社会信号来确定配偶定位的最佳策略。
In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the soil nematode C. elegans, males approach hermaphrodites via the ascaroside pheromones, recognize hermaphrodites when their tails contact the hermaphrodites' body, and eventually mate with them. These processes are mediated by sensory signals specialized for sexual communication, but other mechanisms may also be used to optimize mate location. Here we describe associative learning whereby males use sodium chloride as a cue for hermaphrodite location. Both males and hermaphrodites normally avoid sodium chloride after associative conditioning with salt and starvation. However, we found that males become attracted to sodium chloride after conditioning with salt and starvation if hermaphrodites are present during conditioning. For this conditioning, which we call sexual conditioning, hermaphrodites are detected by males through pheromonal signaling and additional cue(s). Sex transformation experiments suggest that neuronal sex of males is essential for sexual conditioning. Altogether, these results suggest that C. elegans males integrate environmental, internal and social signals to determine the optimal strategy for mate location.
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影响因子：
64.5
作者：
BARGMANN, CI;HARTWIEG, E;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
5.3
作者：
Lipton, J;Kleemann, G;Emmons, SW
通讯作者：
Emmons, SW
影响因子：
10.5
作者：
Mehra, A;Gaudet, J;Spence, AM
通讯作者：
Spence, AM
影响因子：
10.5
作者：
DEBONO, M;ZARKOWER, D;HODGKIN, J
通讯作者：
HODGKIN, J
DOI：
10.1073/pnas.1016232108
发表时间：
2011-05-03
影响因子：
11.1
作者：
Iwata, Ryo;Oda, Shigekazu;Iino, Yuichi
通讯作者：
Iino, Yuichi