Serial progression of cortical and medullary thymic epithelial microenvironments.
Serial progression of cortical and medullary thymic epithelial microenvironments.
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DOI：
10.1002/eji.201344110
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发表时间：
2014-01
影响因子：
5.4
通讯作者：
Jenkinson, William E.
中科院分区：
文献类型：
--
作者：
Alves, Nuno L.;Takahama, Yousuke;Ohigashi, Izumi;Ribeiro, Ana R.;Baik, Song;Anderson, Graham;Jenkinson, William E.
胸腺上皮细胞 (TEC) 为 T 细胞分化提供关键的指导信号。胸腺皮质 (cTEC) 和髓质 (mTEC) 上皮细胞构成了 T 细胞发育的两个功能不同的微环境，它们源自共同的双能 TEC 祖细胞。虽然开创性研究已部分阐明了与 mTEC 及其祖细胞出现相关的双能 TEC 下游事件，但 cTEC 谱系出现的控制和时间，特别是与 mTEC 祖细胞相关的控制和时间，仍然难以捉摸。在这篇综述中，我们描述了解释 cTEC/mTEC 谱系与常见双能祖细胞差异的不同模型。特别是，我们总结了最近在小鼠中的研究，提供了证据表明 mTEC（包括自身免疫调节子+子集）源自最初被赋予通常与 cTEC 谱系相关的表型特性的祖细胞。这些观察结果支持 TEC 发育的新型“串行进展”模型，其中祖细胞在进入 mTEC 分化途径之前连续获得 cTEC 谱系标记。更好地了解 TEC 祖细胞发育早期的表型特性应有助于确定调节 cTEC/mTEC 谱系发育的机制，以及涉及 TEC 治疗的胸腺重建策略。
Thymic epithelial cells (TECs) provide key instructive signals for T-cell differentiation. Thymic cortical (cTECs) and medullary (mTECs) epithelial cells constitute two functionally distinct microenvironments for T-cell development, which derive from a common bipotent TEC progenitor. While seminal studies have partially elucidated events downstream of bipotent TECs in relation to the emergence of mTECs and their progenitors, the control and timing of the emergence of the cTEC lineage, particularly in relation to that of mTEC progenitors, has remained elusive. In this review, we describe distinct models that explain cTEC/mTEC lineage divergence from common bipotent progenitors. In particular, we summarize recent studies in mice providing evidence that mTECs, including the auto-immune regulator+ subset, derive from progenitors initially endowed with phenotypic properties typically associated with the cTEC lineage. These observations support a novel “serial progression” model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway. Gaining a better understanding of the phenotypic properties of early stages in TEC progenitor development should help in determining the mechanisms regulating cTEC/mTEC lineage development, and in strategies aimed at thymus reconstitution involving TEC therapy.
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DOI：
10.4049/jimmunol.0804133
发表时间：
2009-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Laan M;Kisand K;Kont V;Möll K;Tserel L;Scott HS;Peterson P
通讯作者：
Peterson P
影响因子：
29.7
作者：
Boehm T;McCurley N;Sutoh Y;Schorpp M;Kasahara M;Cooper MD
通讯作者：
Cooper MD
影响因子：
4.4
作者：
Alves, Nuno L.;Huntington, Nicholas D.;Di Santo, James P.
通讯作者：
Di Santo, James P.
影响因子：
30.5
作者：
Derbinski, J;Schulte, A;Klein, L
通讯作者：
Klein, L
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D