Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
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DOI：
10.1371/journal.pone.0080570
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gu H
中科院分区：
文献类型：
--
作者：
Yin J;Wang X;Zheng L;Shi Y;Wang L;Shao A;Tang W;Ding G;Liu C;Liu R;Chen S;Gu H
食道癌是全球第八大常见癌症和第六大癌症相关死亡原因。除了环境危险因素外，遗传因素可能在食管癌的发生中起重要作用。我们进行了一项以医院为基础的病例对照研究，以评估MicroRNAs中功能性单核苷酸多态(SNPs)在食道癌发生中的遗传易感性。本研究共收集629例食管鳞癌(ESCC)患者和686例正常对照。用连接检测反应(LDR)法检测hsa-miR-34b/c rs4938723 T>；C、pri-miR-124-1 rs531564 C>；G、Pre-miR-125A rs12975333 G>；T和hsa-miR-423 rs6505162 C>；A等位基因。我们的结果表明，hsa-miR-34b/c rs4938723 CC基因型患ESCC的风险较低。这种关联在从不饮酒的患者中很明显。HSA-miR-423 rs6505162 C>；A可能与吸烟患者ESCC风险显著增加有关。提示hsa-miR-34b/c rs4938723 T>；C和hsa-miR-423 rs6505162 C>；A功能多态可能改变个体对ESCC的易感性。然而，我们的结果是在有限的样本量下获得的。未来需要对其他种族人群进行更大规模的研究，以证实目前的发现。
Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associated death worldwide. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancer carcinogenesis. We conducted a hospital based case–control study to evaluate the genetic susceptibility of functional single nucleotide polymorphisms (SNPs) in the microRNAs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were recruited for this study. The hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T and hsa-miR-423 rs6505162 C>A genotypes were determined using Ligation Detection Reaction (LDR) method. Our results demonstrated that hsa-miR-34b/c rs4938723 CC genotype had a decreased risk of ESCC. The association was evident among patients who never drinking. Hsa-miR-423 rs6505162 C>A might associated with a significantly increased risk of ESCC in patients who smoking. These findings indicated that functional polymorphisms hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A might alter individual susceptibility to ESCC. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations are required to confirm current findings.
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pre-microRNA 基因的遗传多态性作为结直肠癌的预后标志物。
DOI：
10.1158/1055-9965.epi-11-0624
发表时间：
2012-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Xing J;Wan S;Zhou F;Qu F;Li B;Myers RE;Fu X;Palazzo JP;He X;Chen Z;Yang H
通讯作者：
Yang H
影响因子：
7.3
作者：
Kim NH;Kim HS;Kim NG;Lee I;Choi HS;Li XY;Kang SE;Cha SY;Ryu JK;Na JM;Park C;Kim K;Lee S;Gumbiner BM;Yook JI;Weiss SJ
通讯作者：
Weiss SJ
DOI：
10.1146/annurev.pathol.4.110807.092222
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
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作者：
Lee YS;Dutta A
通讯作者：
Dutta A
影响因子：
3.7
作者：
Han Y;Pu R;Han X;Zhao J;Zhang Y;Zhang Q;Yin J;Xie J;Shen Q;Deng Y;Ding Y;Li W;Li J;Zhang H;Cao G
通讯作者：
Cao G
影响因子：
3.7
作者：
Gao, Lin-Bo;Li, Li-Juan;Zhang, Lin
通讯作者：
Zhang, Lin