Effects of cimetidine on the elimination and actions of ethanol.
Effects of cimetidine on the elimination and actions of ethanol.
复制标题
西咪替丁对乙醇消除和作用的影响。
DOI：
10.1001/jama.1982.03320450053036
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Wood
中科院分区：
文献类型：
--
作者：
J. Feely;A. Wood
在一项随机双盲安慰剂对照研究中，对六名志愿者进行了一项随机双盲安慰剂对照研究，研究了盐酸西咪替丁（300 mg，每天四次，持续 7 天）对血浆乙醇浓度的影响以及单次口服乙醇（0.8 g/kg）后中毒的主观评估。与安慰剂相比，西咪替丁使血浆乙醇峰值水平（从 146 +/- 5.2 到 163 +/- 7.6 mg/dL，平均值 +/- SEM）和乙醇浓度时间曲线下面积（从 717 +/- 17 到 771 +/- 44 mg/dLXhr）略有增加。此外，使用视觉模拟量表，受试者在接受西咪替丁时将自己评价为在中毒高峰时更醉。这些结果表明西咪替丁对人体处理乙醇的影响很小。
The influence of cimetidine hydrochloride (300 mg four times daily for seven days) on plasma ethanol concentrations and the subjective assessment of intoxication after a single oral dose of ethanol (0.8 g/kg) were investigated in a randomized double-blind placebo controlled study in six volunteers. Compared with the placebo, cimetidine produced a small increase in both the peak plasma ethanol level (from 146 +/- 5.2 to 163 +/- 7.6 mg/dL, mean +/- SEM) and th area under the ethanol concentration time curve (from 717 +/- 17 to 771 +/- 44 mg/dLXhr). In addition, using a visual analogue scale, subjects rated themselves more intoxicated at their peak of intoxication while receiving cimetidine. These results suggest that cimetidine has a small effect on the handling of ethanol in humans.
西咪替丁减少肝血流量和普萘洛尔代谢。
DOI：
10.1056/nejm198103193041202
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Feely,J;Wilkinson,GR;Wood,AJ
通讯作者：
Wood,AJ