Sense and sensor ability: redox-responsive regulators in Listeria monocytogenes.
Sense and sensor ability: redox-responsive regulators in Listeria monocytogenes.
复制标题
感官和传感器能力:单核细胞增生李斯特菌的氧化还原响应调节剂。
DOI:
10.1016/j.mib.2018.10.006
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发表时间:
2019-03
影响因子:
5.4
通讯作者:
Reniere ML
中科院分区:
文献类型:
--
作者:
Ruhland BR;Reniere ML
Listeria monocytogenes is a Gram-positive bacterium that thrives in nature as a saprophyte and in the mammalian host as an intracellular pathogen. Both environments pose potential danger in the form of redox stress. In addition, endogenous reactive oxygen species (ROS) are continuously generated as by-products of aerobic metabolism. Redox stress from ROS can damage proteins, lipids, and DNA, making it highly advantageous for bacteria to evolve mechanisms to sense and detoxify ROS. This review focuses on the five redox-responsive regulators in Lm: OhrR (to sense organic hydroperoxides), PerR (peroxides), Rex (NAD+/NADH homeostasis), SpxA1/2 (disulfide stress), and PrfA (redox stress during infection).
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Garg, Saurabh K.;Kommineni, Sushma;Zuber, Peter
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