A critique of the vasopressin-memory hypothesis
A critique of the vasopressin-memory hypothesis
复制标题
对加压素记忆假说的批评
DOI：
10.1007/bf00464785
复制
发表时间：
2004
影响因子：
3.4
通讯作者：
A. Sahgal
中科院分区：
文献类型：
--
作者：
A. Sahgal
在过去的20年里，越来越多的证据表明，神经肽加压素(VP)通过作用于中枢机制来增强记忆，而催产素(OT)具有遗忘作用。在这篇综述中，考虑了关于VP的记忆假说的证据，并对不同的解释进行了评估。采用了批判性的方法；突出了否定的发现、设计考虑和各种假设的问题。结论是，记忆假说不能提供足够的解释，并讨论了一些替代的理论和建议。据推测，多肽可能通过两种不同的机制影响行为：外周作用可能涉及强化机制，但其核心作用可能是调节唤醒水平，特别是在应激情况下。
During the past 20 years, evidence has accumulated to suggest that the neuropeptide vasopressin (VP) enhances memory by acting on central mechanisms, and that oxytocin (OT) has amnestic effects. In this review, the evidence for the memory hypothesis with respect to VP is considered and alternative interpretations evaluated. A critical approach has been adopted; negative findings, design considerations and problems with the various hypotheses are given prominence. It is concluded that the memory hypothesis fails to provide an adequate account, and some alternative theories and suggestions are discussed. It is speculated that the peptide may affect behaviour by two distinct mechanisms: peripheral action may involve reinforcement mechanisms, but its central role may be to modulate arousal level, especially in stressful situations.
加压素在脑脊液中表现出有节律的每日模式，但在血液中则不然。
DOI：
10.1126/science.7268432
发表时间：
1981
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Reppert,SM;Artman,HG;Swaminathan,S;Fisher,DA
通讯作者：
Fisher,DA
DOI：
--
发表时间：
1981
期刊：
Advances in biochemical psychopharmacology
影响因子：
--
作者：
Pardridge,WM;Frank,HJ;Cornford,EM;Braun,LD;Crane,PD;Oldendorf,WH
通讯作者：
Oldendorf,WH