The Use of Procalcitonin in the Diagnosis of Acute Appendicitis: A Systematic Review.
The Use of Procalcitonin in the Diagnosis of Acute Appendicitis: A Systematic Review.
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DOI：
10.7759/cureus.30292
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Dale L
中科院分区：
文献类型：
--
作者：
Dale L
背景：急性阑尾炎（AA）是最常见的外科病理之一。其诊断通常基于临床体征和症状进行，并进行额外的微创测试（即，血液检查，以支持诊断。降钙素原（PCT）是一种相对较新的生物标志物，临床医生开始将其用于患有各种感染的住院患者。其水平可用于识别感染的存在。本综述的目的是评估PCT作为生物标志物在支持临床医生评估疑似阑尾炎患者中的有用性。方法：进行了系统的文献检索，共产生了16篇被认为适合评价的主要研究论文。结果：PCT在辅助诊断AA中的有用性取决于阑尾炎的严重程度。与单纯性阑尾炎（UAA）和其他各种非阑尾性腹腔内病变患者相比，发生穿孔、坏疽或坏死等复杂性阑尾炎（CAA）的患者PCT水平显著升高（p<0.05）。结论：PCT在UAA中的应用较弱，然而，PCT被认为有助于预测CAA，从而有助于描述感染的严重程度。反过来，这将有助于确保患者及时安全地被送往手术室进行随后的阑尾切除术。
Background: Acute appendicitis (AA) is one of the most common surgical pathologies. Its diagnosis is often carried out based on clinical signs and symptoms, with additional minimally invasive tests (i.e., blood testing) done to support the diagnosis. Procalcitonin (PCT) is a relatively novel biomarker that is starting to be used by clinicians for patients admitted into hospitals with a variety of infections. Its level can be used to identify the presence of infection. The aim of this review is to assess how useful PCT is as a biomarker in supporting clinicians' assessment of patients with suspected appendicitis. Methods: A systematic literature search was carried out, yielding a total of 16 primary research papers deemed appropriate for appraisal. Results: The usefulness of PCT in aiding the diagnosis of AA depends on the severity of appendicitis. Patients who experience complicated appendicitis (CAA) such as perforation, gangrene, or necrosis have a significantly raised PCT level (p<0.05) compared to those with uncomplicated appendicitis (UAA) and a variety of other non-appendiceal intra-abdominal pathologies. Conclusions: The use of PCT in UAA is weak, however, PCT was deemed useful in helping predict CAA, thus helping portray the severity of infection. This, in turn, will help ensure patients are taken to the operating theatre in a timely and safe manner for subsequent appendicectomy.
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影响因子：
1.6
作者：
Sand, M.;Trullen, X. V.;Mann, B.
通讯作者：
Mann, B.
影响因子：
1.4
作者：
Rastogi, Vaibhav;Singh, Devina;Yale, Steven H.
通讯作者：
Yale, Steven H.
影响因子：
2.9
作者：
Wu, Jie;Jiang, Haiyang;Li, Shikuan;Wu, Xiuwen;Wang, Peige;Sawyer, Robert;Ren, Jianan
通讯作者：
Ren, Jianan
DOI：
10.1097/sle.0000000000000067
发表时间：
2014-12-01
影响因子：
1
作者：
Abbas, Muhammad H.;Choudhry, Muhammad N.;Ammori, Basil J.
通讯作者：
Ammori, Basil J.
影响因子：
3.6
作者：
Kaya, Bulent;Sana, Baris;Kutanis, Riza
通讯作者：
Kutanis, Riza