Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV.
Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV.
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DOI：
10.1002/hbm.25634
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发表时间：
2021-11
影响因子：
4.8
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Christopher-Hayes NJ;Lew BJ;Wiesman AI;Schantell M;O'Neill J;May PE;Swindells S;Wilson TW
艾滋病毒感染者（PWH）使用大麻的比例高于普通人群，但对神经活动的影响尚未得到很好的表征。在PWH中使用大麻可能具有有益的效果，因为已知神经炎症是PWH的关键问题，并且大麻的使用与促炎标志物的减少有关。因此，重要的是要了解使用大麻对PWH大脑和认知功能的净影响。在这项研究中，我们收集了81名参与者的脑磁图（MEG）脑成像数据，这些参与者分为四个人口统计学匹配的组（即，使用大麻的PWH、使用大麻的对照、不使用PWH和不使用对照）。参与者在MEG期间完成视觉空间处理任务。提取时间-频率分辨的体素时间序列以识别振荡和刺激前基线神经活动的动力学。我们的研究结果表明，所有参与者的顶枕脑区域都存在强烈的theta（4-8 Hz），alpha（10-16 Hz）和gamma（62-72 Hz）视觉振荡。PWH在视觉空间处理中表现出显著的行为缺陷，以及视觉皮层中θ振荡减少和刺激前γ活动升高，所有这些都重复了先前的工作。引人注目的是，长期使用大麻与视觉皮层中刺激前伽马活动的显着减少有关，因此PWH与对照组不再有统计学差异。这些结果提供了初步的证据表明，大麻的使用可能会使PWH的一些神经畸变正常化。这项研究填补了了解大麻使用对PWH大脑和认知功能影响的重要空白。这项工作使用了视觉空间处理范式结合脑磁图（MEG）成像。体素水平的时间序列分析被应用于研究大麻使用对艾滋病毒感染者（PWH）行为和神经活动的影响。
People with HIV (PWH) use cannabis at a higher rate than the general population, but the influence on neural activity is not well characterized. Cannabis use among PWH may have a beneficial effect, as neuroinflammation is known to be a critical problem in PWH and cannabis use has been associated with a reduction in proinflammatory markers. Thus, it is important to understand the net impact of cannabis use on brain and cognitive function in PWH. In this study, we collected magnetoencephalographic (MEG) brain imaging data on 81 participants split across four demographically matched groups (i.e., PWH using cannabis, controls using cannabis, non‐using PWH, and non‐using controls). Participants completed a visuospatial processing task during MEG. Time–frequency resolved voxel time series were extracted to identify the dynamics of oscillatory and pre‐stimulus baseline neural activity. Our results indicated strong theta (4–8 Hz), alpha (10–16 Hz), and gamma (62–72 Hz) visual oscillations in parietal–occipital brain regions across all participants. PWH exhibited significant behavioral deficits in visuospatial processing, as well as reduced theta oscillations and elevated pre‐stimulus gamma activity in visual cortices, all of which replicate prior work. Strikingly, chronic cannabis use was associated with a significant reduction in pre‐stimulus gamma activity in the visual cortices, such that PWH no longer statistically differed from controls. These results provide initial evidence that cannabis use may normalize some neural aberrations in PWH. This study fills an important gap in understanding the impact of cannabis use on brain and cognitive function in PWH. This work used a visuospatial processing paradigm in combination with magnetoencephalographic (MEG) imaging. Voxel‐level timeseries analyses were applied to study the impact of cannabis use on behavior and neural activity in people with HIV (PWH).
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影响因子：
16.2
作者：
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通讯作者：
Fries P
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