Altered low-frequency brain rhythms precede changes in gamma power during tauopathy.
Altered low-frequency brain rhythms precede changes in gamma power during tauopathy.
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DOI：
10.1016/j.isci.2022.105232
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发表时间：
2022-10-21
期刊：
影响因子：
5.8
通讯作者：
Solomon, Samuel G.
中科院分区：
文献类型：
--
作者：
Rodrigues, Fabio R.;Papanikolaou, Amalia;Holeniewska, Joanna;Phillips, Keith G.;Saleem, Aman B.;Solomon, Samuel G.
神经退行性疾病与大脑活动和大脑节律的广泛破坏有关。一些疾病与膜相关蛋白Tau的功能障碍有关。在这里，我们询问在tau蛋白病的rTg 4510小鼠模型中，在tau蛋白病的早期阶段（5个月）和更晚期阶段（8个月），脑节律如何受到影响。我们在有或没有视觉刺激的情况下测量初级视觉皮层的脑节律，同时监测瞳孔直径和运动以建立行为状态。在5个月时，我们发现tau蛋白病动物在静息状态下低频节律增加，与异常增加的神经同步期有关。在8个月时，这种低频节律的增加伴随着伽马范围内功率的降低。因此，我们的研究结果表明，在这种tau蛋白病模型中，较慢的节律比γ节律更早受损，并表明电生理测量可以跟踪tau蛋白病神经变性的进展。rTg 4510动物在疾病的早期阶段V1中的低频功率增加在退化后的后期阶段，V1 γ功率降低在tau蛋白病中低频节律彼此更强烈地耦合生物科学;神经科学;临床神经科学;认知神经科学
Neurodegenerative disorders are associated with widespread disruption to brain activity and brain rhythms. Some disorders are linked to dysfunction of the membrane-associated protein Tau. Here, we ask how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of tauopathy (5 months), and at a more advanced stage (8 months). We measured brain rhythms in primary visual cortex in presence or absence of visual stimulation, while monitoring pupil diameter and locomotion to establish behavioral state. At 5 months, we found increased low-frequency rhythms during resting state in tauopathic animals, associated with periods of abnormally increased neural synchronization. At 8 months, this increase in low-frequency rhythms was accompanied by a reduction of power in the gamma range. Our results therefore show that slower rhythms are impaired earlier than gamma rhythms in this model of tauopathy, and suggest that electrophysiological measurements can track the progression of tauopathic neurodegeneration. rTg4510 animals have increased low-frequency power in V1 at early stages of disease At later stages, following degeneration, V1 gamma power is reduced Low-frequency rhythms are more strongly coupled with each other in tauopathy Biological sciences; Neuroscience; Clinical neuroscience; Cognitive neuroscience
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影响因子：
4.6
作者：
Ahnaou A;Moechars D;Raeymaekers L;Biermans R;Manyakov NV;Bottelbergs A;Wintmolders C;Van Kolen K;Van De Casteele T;Kemp JA;Drinkenburg WH
通讯作者：
Drinkenburg WH
影响因子：
16.2
作者：
Chen G;Zhang Y;Li X;Zhao X;Ye Q;Lin Y;Tao HW;Rasch MJ;Zhang X
通讯作者：
Zhang X
影响因子：
1.7
作者：
Bruns, A;Eckhorn, R;Ebner, A
通讯作者：
Ebner, A
影响因子：
5.3
作者：
Booth, Clair A.;Witton, Jonathan;Brown, Jonathan T.
通讯作者：
Brown, Jonathan T.
影响因子：
5.3
作者：
Curto, Carina;Sakata, Shuzo;Harris, Kenneth D.
通讯作者：
Harris, Kenneth D.