Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites.
Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites.
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DOI：
10.1007/s10552-012-0090-z
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发表时间：
2013-01
影响因子：
2.3
通讯作者：
Wiggins, Charles L.
中科院分区：
文献类型：
--
作者：
Cook, Linda S.;Nelson, Harold E.;Cockburn, Myles;Olson, Sara H.;Muller, Carolyn Y.;Wiggins, Charles L.
我们调查了合并症和子宫内膜癌的生存种族，因为西班牙裔白人（HWs）的生存比非西班牙裔白人（NHWs）。一个子宫内膜癌队列（1992-2004年）建立了监测，流行病学和最终结果-医疗保险链接的数据库（n=3286）进行了跟踪到2007年。采用多变量风险比（mHR）评估子宫内膜癌特异性和其他原因死亡率。HWs比NHWs更可能患有局部/远处疾病（31.7% vs. 24.8%）、糖尿病（31.7% vs. 11.0%）和高血压（49.4% vs. 37.6%）。HWs的子宫内膜癌特异性生存率低于NHWs（年龄调整HR=1.28; 95%CI 1.01-1.61），但在调整肿瘤特征和治疗后，差异不显著（mHR=1.02; 95%CI 0.81-1.29）。相比之下，即使在调整了癌症相关因素后，HWs的其他原因死亡率仍升高（mHR=1.27; 95%CI 1.01-1.59），但在进一步调整了共病条件后没有升高（mHR=1.07; 95%CI 0.85-1.35）。合并症，特别是糖尿病，在HWs中比NHWs更常见，并影响其他原因的死亡率。改善糖尿病管理可能是改善其他原因死亡率的有效手段。这可能是特别真实的保健工作者，因为他们特别高的糖尿病患病率。
We investigated comorbidities and endometrial cancer survival by ethnicity because Hispanic whites (HWs) have worse survival than non-Hispanic whites (NHWs). An endometrial cancer cohort (1992–2004) established with the Surveillance, Epidemiology and End Results-Medicare linked database (n=3286) was followed through 2007. Endometrial cancer-specific and other cause mortality were evaluated with multivariate hazard ratios (mHRs). HWs were more likely than NHWs to have regional/distant disease (31.7% vs. 24.8%), diabetes (31.7% vs. 11.0%), and hypertension (49.4% vs. 37.6%). HWs had poorer endometrial cancer-specific survival than NHWs (age-adjusted HR=1.28; 95%CI 1.01–1.61), but not after adjustment for tumor characteristics and treatment (mHR=1.02; 95%CI 0.81–1.29). In contrast, even after adjustment for cancer-related factors, other cause mortality in HWs was elevated (mHR=1.27; 95%CI 1.01–1.59), but not after further adjustment for comorbid conditions (mHR=1.07; 95%CI 0.85–1.35). Comorbidities, particularly diabetes, were more common in HWs than NHWs and impacted other cause mortality. Improving diabetes management may be an effective means of improving other cause mortality. This may be particularly true for HWs, given their particularly high prevalence of diabetes.
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影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
2.3
作者：
Clegg, Limin X.;Reichman, Marsha E.;Edwards, Brenda K.
通讯作者：
Edwards, Brenda K.
影响因子：
6.4
作者：
Braithwaite, Dejana;Tammemagi, C. Martin;Esserman, Laura
通讯作者：
Esserman, Laura
影响因子：
16.2
作者：
Cowie, Catherine C.;Engelgau, Michael M.;Gregg, Edward W.
通讯作者：
Gregg, Edward W.
影响因子：
5.4
作者：
Cook, Linda S.;Kmet, Leanne M.;Weiss, Noel S.
通讯作者：
Weiss, Noel S.