Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb

Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb
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通过组蛋白乙酰化和 mRNA 延伸因子 BRD4-P-TEFb 调节小鼠小肠中 Sglt1 的昼夜节律表达

DOI:
10.1080/09168451.2018.1451743
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发表时间:
2018
期刊:
Bioscience, Biotechnology, and Biochemistry
影响因子:
--
通讯作者:
Goda Toshinao
Goda Toshinao
中科院分区:
--
文献类型:
--
作者:
Yamauchi Hiroyuki;Honma Kazue;Mochizuki Kazuki;Goda Toshinao

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空肠钠/葡萄糖共转运蛋白(SGLT1)具有昼夜节律性表达。每隔4小时收集一次小鼠的空肠,我们检测了组蛋白乙酰化和基因周围含溴结构域蛋白-4(BRD4)的结合。在基因诱导之前,Sglt1转录区域的组蛋白乙酰化增加。此外,该基因周围的mRNA延伸因子的结合呈现昼夜节律。
Jejunal sodium/glucose co-transporter (Sglt1) displays circadian expression. The jejunum was collected every 4 h from mice, and we examined histone acetylation and binding of bromodomain-containing protein-4 (BRD4) around of the gene. Histone acetylation increased in the transcribed region ofSglt1prior to induction of the gene. Furthermore, the binding of mRNA elongation factor around the gene showed circadian rhythm.
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