Adenosine signaling and the energetic costs of induced immunity.
Adenosine signaling and the energetic costs of induced immunity.
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DOI：
10.1371/journal.pbio.1002136
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发表时间：
2015-04
期刊：
影响因子：
9.8
通讯作者：
Lazzaro BP
中科院分区：
文献类型：
--
作者：
Lazzaro BP
生活史理论预测，性状的进化应该受到生物体上相互竞争的生理需求的限制。免疫防御提供了一个经典的例子，其中免疫反应被认为是昂贵的，因此以牺牲与适应性相关的其他特征为代价。降低昂贵性状成本的一种策略是使其具有诱导性，这样只有在利用该性状时才支付成本。在最新一期的PLOS Biology中，Bajgar及其同事优雅地证明了果蝇幼虫在感染寄生蜂Leptopilina boulardi后诱导的免疫反应的能量和生命史成本。这些作者表明，感染诱导的防御性血细胞增殖命令膳食碳从体细胞生长和发育中转移，单糖被分流到造血器官，快速转化为细胞增殖所需的原始能量。这种代谢转变导致受感染幼虫发育延迟15%，并由宿主果蝇造血器官和中央代谢控制器官之间的腺苷信号传导介导。腺苷信号因此允许D.黑腹果蝇能够迅速调动有效防御所需的能量，只有在感染时才能支付免疫力的代价。被寄生蜂感染的果蝇利用腺苷信号从组织生长中募集能量，以支持防御性免疫细胞的增殖，从而支付诱导免疫的部署成本。阅读研究文章。
Life history theory predicts that trait evolution should be constrained by competing physiological demands on an organism. Immune defense provides a classic example in which immune responses are presumed to be costly and therefore come at the expense of other traits related to fitness. One strategy for mitigating the costs of expensive traits is to render them inducible, such that the cost is paid only when the trait is utilized. In the current issue of PLOS Biology, Bajgar and colleagues elegantly demonstrate the energetic and life history cost of the immune response that Drosophila melanogaster larvae induce after infection by the parasitoid wasp Leptopilina boulardi. These authors show that infection-induced proliferation of defensive blood cells commands a diversion of dietary carbon away from somatic growth and development, with simple sugars instead being shunted to the hematopoetic organ for rapid conversion into the raw energy required for cell proliferation. This metabolic shift results in a 15% delay in the development of the infected larva and is mediated by adenosine signaling between the hematopoietic organ and the central metabolic control organ of the host fly. The adenosine signal thus allows D. melanogaster to rapidly marshal the energy needed for effective defense and to pay the cost of immunity only when infected. Fruit flies infected by a parasitoid wasp use adenosine signaling to recruit energy away from tissue growth in order to support proliferation of defensive immune cells, thereby paying a deployment cost of inducible immunity. Read the Research Article.
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炎症反应期间，果蝇腺苷脱氨酶在免疫细胞中的表达。
影响因子：
3.7
作者：
Novakova M;Dolezal T
通讯作者：
Dolezal T
影响因子：
9.8
作者：
Bajgar A;Kucerova K;Jonatova L;Tomcala A;Schneedorferova I;Okrouhlik J;Dolezal T
通讯作者：
Dolezal T
影响因子：
2
作者：
ZAHAVI, A
通讯作者：
ZAHAVI, A
影响因子：
4.1
作者：
Long, Grainne H.;Graham, Andrea L.
通讯作者：
Graham, Andrea L.
影响因子：
2.9
作者：
LAW, R
通讯作者：
LAW, R