Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.
Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.
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DOI：
10.1111/vco.12037
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发表时间：
2015-09
影响因子：
2.1
通讯作者：
Rosol TJ
中科院分区：
文献类型：
--
作者：
Martin CK;Dirksen WP;Carlton MM;Lanigan LG;Pillai SP;Werbeck JL;Simmons JK;Hildreth BE 3rd;London CA;Toribio RE;Rosol TJ
口腔鳞状细胞癌在猫和人类中很常见，并且侵犯口腔骨。我们假设环氧合酶-2抑制剂美洛昔康与双膦酸盐唑来膦酸（ZOL）联合使用，可以抑制猫口腔鳞状细胞癌（OSCC）小鼠异种移植瘤的肿瘤生长、骨质溶解和侵袭。人和猫OSCC细胞系表达环氧合酶（考克斯）-1和2，SCCF 2细胞在骨条件培养基中表达增加考克斯-2 mRNA。将表达荧光素酶的猫SCCF 2Luc细胞注射到上颌骨周围牙龈下方，小鼠接受0.1 mg/kg ZOL每周两次、0.3 mg/kg美洛昔康每日一次、ZOL和美洛昔康联合给药或溶剂给药。ZOL可抑制肿瘤-骨界面的骨吸收。美洛昔康在减少异种移植物生长方面比ZOL更有效，但不影响骨吸收。虽然没有观察到ZOL和美洛昔康联合治疗的协同作用，但联合治疗耐受性良好，可能有助于骨侵袭性猫OSCC的临床治疗。
Oral squamous cell carcinoma is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase-2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumor growth, osteolysis and invasion in feline oral squamous cell carcinoma (OSCC) xenografts in mice. Human and feline OSCC cell lines expressed cyclooxygenase (COX)-1 and 2 and the SCCF2 cells had increased COX-2 mRNA expression with bone conditioned medium. Luciferase-expressing feline SCCF2Luc cells were injected beneath the perimaxillary gingiva and mice were treated with 0.1 mg/kg ZOL twice weekly, 0.3 mg/kg meloxicam daily, combined ZOL and meloxicam, or vehicle. ZOL inhibited osteoclastic bone resorption at the tumor-bone interface. Meloxicam was more effective than ZOL at reducing xenograft growth but did not affect osteoclastic bone resorption. Although a synergistic effect of combined ZOL and meloxicam was not observed, combination therapy was well tolerated and may be useful in the clinical management of bone-invasive feline OSCC.
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影响因子：
0.8
作者：
Hayes, A.;Scase, T.;Adams, V.
通讯作者：
Adams, V.
联合卡利他汀基因疗法和美洛昔康治疗小鼠肝细胞癌
影响因子：
5.7
作者：
Jiang, Xian;Li, Hali;Sun, Xueying
通讯作者：
Sun, Xueying
影响因子：
6.2
作者：
Luckman, SP;Hughes, DE;Rogers, MJ
通讯作者：
Rogers, MJ
影响因子：
4.8
作者：
Martin, Chelsea K.;Dirksen, Wessel P.;Rosol, Thomas J.
通讯作者：
Rosol, Thomas J.
影响因子：
2.1
作者：
Bergkvist, G. T.;Argyle, D. J.;Yool, D. A.
通讯作者：
Yool, D. A.