Cutaneous immunization: an evolving paradigm in influenza vaccines.
Cutaneous immunization: an evolving paradigm in influenza vaccines.
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DOI：
10.1517/17425247.2014.885947
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发表时间：
2014-04
影响因子：
6.6
通讯作者：
Compans RW
中科院分区：
文献类型：
--
作者：
Gill HS;Kang SM;Quan FS;Compans RW
大多数疫苗通过使用皮下注射针头和注射器的肌肉注射来施用。这一程序的一些局限性包括由于害怕针刺而不愿意接种疫苗，以及与使用后安全处置针头有关的问题。皮肤递送是一种替代的疫苗接种途径，有可能是无痛的，甚至可能导致疫苗剂量减少。最近，微针已经成为一种新型的无痛方法，用于通过皮肤递送流感疫苗。本文简要综述了皮肤接种的方法和装置，重点介绍了微针皮肤接种流感疫苗的研究。我们讨论了功能性免疫反应和这种免疫反应的性质后接种微针。使用微针进行流感疫苗皮肤接种具有几个优点：无痛，在临床前研究中引起更强的免疫反应，并且可以改善高危人群的反应。这些疫苗的干燥制剂提供了增强的稳定性，这是一种非常重要的性质，能够使其在应对可能爆发的大流行性流感和新出现的传染病时迅速在全球分布。
Most vaccines are administered by intramuscular injection using a hypodermic needle and syringe. Some limitations of this procedure include reluctance to be immunized because of fear of needlesticks, and concerns associated with the safe disposal of needles after their use. Skin delivery is an alternate route of vaccination that has potential to be painless and could even lead to dose reduction of vaccines. Recently, microneedles have emerged as a novel painless approach for delivery of influenza vaccines via the skin. In this review, we briefly summarize the approaches and devices used for skin vaccination, and then focus on studies of skin immunization with influenza vaccines using microneedles. We discuss both the functional immune response and the nature of this immune response following vaccination with microneedles. The cutaneous administration of influenza vaccines using microneedles offers several advantages: it is painless, elicits stronger immune responses in preclinical studies and could improve responses in high-risk populations. These dry formulations of vaccines provide enhanced stability, a property of high importance in enabling their rapid global distribution in response to possible outbreaks of pandemic influenza and newly emerging infectious diseases.
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影响因子：
10.8
作者：
Choi, Hyo-Jick;Bondy, Brian J.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
5.5
作者：
Drape, Robert J.;Macklin, Michael D.;Dean, Hansi J.
通讯作者：
Dean, Hansi J.
影响因子：
4.6
作者：
Gill, Harvinder S.;Andrews, Samantha N.;Sakthivel, Senthilkumar K.;Fedanov, Andrew;Williams, Ifor R.;Garber, David A.;Priddy, Frances H.;Yellin, Seth;Feinberg, Mark B.;Staprans, Silvija I.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
6.6
作者：
Dean, Hansi J
通讯作者：
Dean, Hansi J
影响因子：
6.2
作者：
Ansaldi, Filippo;de Florentiis, Daniela;Icardi, Giancarlo
通讯作者：
Icardi, Giancarlo