Selective removal of stratum corneum by microdermabrasion to increase skin permeability.
Selective removal of stratum corneum by microdermabrasion to increase skin permeability.
复制标题
DOI：
10.1016/j.ejps.2009.06.004
复制
发表时间：
2009-09-10
影响因子：
4.6
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Gill, Harvinder S.;Andrews, Samantha N.;Sakthivel, Senthilkumar K.;Fedanov, Andrew;Williams, Ifor R.;Garber, David A.;Priddy, Frances H.;Yellin, Seth;Feinberg, Mark B.;Staprans, Silvija I.;Prausnitz, Mark R.
关键词：
本研究旨在确定微晶磨皮术是否可以选择性地去除角质层以增加皮肤渗透性。尽管微晶磨皮已用于皮肤美容治疗数十年，但尚未有研究评估微晶磨皮条件对皮肤组织去除程度的详细影响。因此，我们在不同条件下微晶磨皮后，对恒河猴和人类志愿者的皮肤进行组织学表征。使用移动的尖端微晶磨皮，治疗次数的增加导致更大的组织去除，范围从最小的影响到对皮肤深层的广泛损伤。值得注意的是，这些数据首次表明，在适度的微晶磨皮条件下，可以实现选择性但全厚度的角质层去除，而对更深的皮肤组织几乎没有损伤。在微晶磨皮的静止模式下，没有观察到选择性角质层去除，但可以看到微水泡。在人类志愿者中观察到类似的组织去除趋势。作为药物递送应用的概念证明，模型荧光药物（荧光素）通过微磨皮皮肤递送，并且在猴中局部施用后产生针对牛痘病毒的抗体。总之，微晶磨皮可以选择性地去除全层角质层，对深层组织的损伤很小，从而增加皮肤的渗透性。
This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of skin tissue removal. Therefore, we histologically characterized the skin of rhesus macaques and human volunteers after microdermabrasion at different conditions. Using mobile tip microdermabrasion, an increase in the number of treatment passes led to greater tissue removal ranging from minimal effects to extensive damage to deeper layers of the skin. Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues. In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen. Similar tissue removal trends were observed in human volunteers. As proof of concept for drug delivery applications, a model fluorescent drug (fluorescein) was delivered through microdermabraded skin and antibodies were generated against vaccinia virus after its topical application in monkeys. In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.
登录
查看更多内容
影响因子：
2.4
作者：
Lee, Woan-Ruoh;Tsai, Ren-Yeu;Fang, Jia-You
通讯作者：
Fang, Jia-You
DOI：
10.1073/pnas.2331316100
发表时间：
2003-11-25
影响因子：
11.1
作者：
McAllister, DV;Wang, PM;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
46.9
作者：
Prausnitz, Mark R.;Langer, Robert
通讯作者：
Langer, Robert
影响因子：
3.1
作者：
Glenn, Gregory M.;Villar, Christina P.;Frech, Sarah A.
通讯作者：
Frech, Sarah A.
影响因子：
7.3
作者：
Spencer, JM
通讯作者：
Spencer, JM