The psychosis human connectome project: An overview.

The psychosis human connectome project: An overview.
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DOI:
10.1016/j.neuroimage.2021.118439
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发表时间:
2021-11-01
期刊:
影响因子:
5.7
通讯作者:
Sponheim SR
Sponheim SR
中科院分区:
医学1区
文献类型:
--
作者:
Demro C;Mueller BA;Kent JS;Burton PC;Olman CA;Schallmo MP;Lim KO;Sponheim SR

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人类连接组项目的研究范围已经扩大到包括专注于大脑疾病的研究。本文介绍了一个调查集中在精神病的精神病理学:精神病人类连接组计划(P-HCP)。作为该项目的一部分收集的数据是多模态的,来自精神病理学的临床评估、认知评估、基于仪器的运动评估、血液标本和磁共振成像(MRI)数据。该数据集将通过NIMH数据档案公开提供。在这份报告中,我们提供了具体的信息,参与者的样本是如何获得和表征,并描述了实验任务和程序,用于探测神经功能参与精神障碍,也可能标志着遗传倾向的精神病性精神病理学。我们在本文中的目标是概述数据采集过程,以便打算使用这些公开数据的研究人员可以计划他们的分析。本文中描述的MRI数据仅限于在3特斯拉下采集的数据。一篇配套论文详细描述了这项研究的7特斯拉图像采集协议,重点是精神病性精神病理学中的视觉感知功能。
Investigations within the Human Connectome Project have expanded to include studies focusing on brain disorders. This paper describes one of the investigations focused on psychotic psychopathology: The psychosis Human Connectome Project (P-HCP). The data collected as part of this project were multimodal and derived from clinical assessments of psychopathology, cognitive assessments, instrument-based motor assessments, blood specimens, and magnetic resonance imaging (MRI) data. The dataset will be made publicly available through the NIMH Data Archive. In this report we provide specific information on how the sample of participants was obtained and characterized and describe the experimental tasks and procedures used to probe neural functions involved in psychotic disorders that may also mark genetic liability for psychotic psychopathology. Our goal in this paper is to outline the data acquisition process so that researchers intending to use these publicly available data can plan their analyses. MRI data described in this paper are limited to data acquired at 3 Tesla. A companion paper describes the study’s 7 Tesla image acquisition protocol in detail, which is focused on visual perceptual functions in psychotic psychopathology.
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