ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome.
ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome.
复制标题
DOI：
10.1038/bjc.2013.297
复制
发表时间：
2013-07-09
影响因子：
8.8
通讯作者：
Tan PH
中科院分区：
文献类型：
--
作者：
Tan EY;Thike AA;Breast Surgical Team at Outram;Tan PH
发生在年轻女性身上的肿瘤似乎在生物学上更具侵略性，并且往往具有较差的结果。乳腺癌干细胞（CSCs）对常规治疗具有相对抵抗力，被认为是治疗后疾病复发的可能原因。在这项研究中，我们使用ALDH 1作为CSC标志物，并确定ALDH 1表达是否与年轻女性乳腺癌的临床结果相关。ALDH 1的表达通过免疫组化在从141个连续的35岁以下的患者获得的微阵列核心上进行评估。在25%（141例中的35例）的肿瘤中观察到ALDH 1的表达，中位数为5%的细胞。年轻女性患ALDH 1阳性肿瘤的可能性高14倍（P<0.01，OR 14.4，95% CI 4.34-48.09）。ALDH 1与ER阴性独立相关（P=0.01，OR 0.33，95%CI 0.15-0.77）。与疾病复发或乳腺癌相关死亡无关。在年轻女性中，ALDH 1表达更高，并且与ER阴性相关。然而，在这项研究中，它并不能预测生存率。
Tumours arising in younger women appear to be biologically more aggressive and tend to have a poorer outcome. Being relatively resistant to conventional treatments, breast cancer stem cells (CSCs) have been postulated as a possible cause of disease recurrence after treatment. In this study, we used ALDH1 as a CSC marker and determined whether ALDH1 expression correlated with clinical outcome in young women with breast cancer. The expression of ALDH1 was evaluated through immunohistochemistry on microarrayed cores obtained from 141 consecutive patients up to 35 years of age. The expression of ALDH1 was observed in 25% (35 of 141) of tumours, in a median of 5% of cells. Younger women were 14 times more likely to have ALDH1-positive tumours (P<0.01, OR 14.4, 95% CI 4.34–48.09). The ALDH1 correlated independently with ER negativity (P=0.01, OR 0.33, 95% CI 0.15–0.77). There was no correlation with disease recurrence or breast cancer-related deaths. In younger women, ALDH1 was more highly expressed, and it correlated with ER negativity. It, however, did not predict survival in this study.
登录
查看更多内容
影响因子：
2.5
作者：
Shi, Wen;Harris, Adrian L.
通讯作者：
Harris, Adrian L.
影响因子：
45.3
作者：
Liedtke, Cornelia;Mazouni, Chafika;Pusztai, Lajos
通讯作者：
Pusztai, Lajos
影响因子：
45.3
作者：
Anders, Carey K.;Hsu, David S.;Blackwell, Kimberly L.
通讯作者：
Blackwell, Kimberly L.
影响因子：
11.5
作者：
Tanei, Tomonori;Morimoto, Koji;Noguchi, Shinzaburo
通讯作者：
Noguchi, Shinzaburo
影响因子：
4.5
作者：
De Brot, Marina;Rocha, Rafael M.;Gobbi, Helene
通讯作者：
Gobbi, Helene