Chlorophagy does not require PLANT U-BOX4-mediated ubiquitination
Chlorophagy does not require PLANT U-BOX4-mediated ubiquitination
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噬菌体不需要 PLANT U-BOX4 介导的泛素化
DOI：
10.1080/15592324.2020.1861769
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发表时间：
2020
影响因子：
2.9
通讯作者：
Izumi Masanori
中科院分区：
文献类型：
--
作者：
Nakamura Sakuya;Izumi Masanori
叶绿体和线粒体作为细胞内的能量产生场所，由其膜中的电子传输链提供动力。这些细胞器不断积累损伤，因为它们的能量反应产生了活性氧物种。为了防止受损细胞器的积累和细胞内稳态的破坏，真核细胞必须去除受损的线粒体和叶绿体。自噬是细胞器降解的主要途径。一种称为有丝分裂吞噬的线粒体靶向自噬去除了哺乳动物细胞中受损的线粒体；失去膜潜力的功能障碍的线粒体以蛋白质泛素化为标志，成为选择性有丝分裂吞噬的目标。对植物叶绿体质量控制系统的研究表明，自噬和泛素化都参与了受损叶绿体的降解。我们最近评估了植物U-BOX4(PUB4)介导的叶绿体相关泛素化与氧化损伤叶绿体周转中叶绿体靶向自噬(噬叶体)之间的关系。利用拟南芥突变体进行的多次分析表明，PUB4相关的泛素化对于诱导嗜氯是必不可少的。在这里，我们描述了PUB4和嗜叶绿体在叶绿体周转和植物生长中的平行功能。
Chloroplasts and mitochondria serve as intracellular energy production sites that are powered by the electron transport chain in their membranes. These organelles constantly accumulate damage, as their energetic reactions generate reactive oxygen species. To prevent the accumulation of damaged organelles and perturbation of cellular homeostasis, eukaryotic cells must remove damaged mitochondria and chloroplasts. Autophagy is the main route by which organelles are degraded. A type of mitochondrion-targeted autophagy known as mitophagy removes damaged mitochondria in mammalian cells; dysfunctional mitochondria that lose their membrane potential are marked by protein ubiquitination, becoming targets of selective mitophagy. Studies of the quality control system for chloroplasts in plants revealed the involvement of both autophagy and ubiquitination in the degradation of damaged chloroplasts. We recently assessed the relationship between chloroplast-associated ubiquitination mediated by PLANT U-BOX4 (PUB4) and chloroplast-targeted autophagy (chlorophagy) in the turnover of oxidatively damaged chloroplasts. Multiple assays using anArabidopsis thalianamutant revealed that PUB4-associated ubiquitination is dispensable for the induction of chlorophagy. Here, we describe the parallel functions of PUB4 and chlorophagy in chloroplast turnover and plant growth.
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DOI：
--
发表时间：
2013
期刊：
影响因子：
--
作者：
Norihiro Takekawa;Seiji Kojima;Michio Homma;T NODA
通讯作者：
T NODA
通过微自噬选择性消除膜损伤的叶绿体1[打开]
影响因子：
7.4
作者：
Sakuya Nakamura;J. Hidema;W. Sakamoto;H. Ishida;M. Izumi
通讯作者：
M. Izumi
自噬为氨基酸分解代谢途径提供底物，作为拟南芥对糖饥饿的适应性反应
DOI：
--
发表时间：
2016
期刊：
影响因子：
--
作者：
Ishida;H.
通讯作者：
H.
DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
Taichi Sugawara;Kyoko Furuse;Tetsuhisa Otani;Mikio Furuse;Koji Yamano
通讯作者：
Koji Yamano
影响因子：
11.8
作者：
Anding AL;Baehrecke EH
通讯作者：
Baehrecke EH