Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices.
Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices.
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DOI：
10.1126/sciadv.abc5630
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发表时间：
2020-10
期刊：
影响因子：
13.6
通讯作者：
Kong H
中科院分区：
文献类型：
--
作者：
Kim BS;Kim MK;Cho Y;Hamed EE;Gillette MU;Cha H;Miljkovic N;Aakalu VK;Kang K;Son KN;Schachtschneider KM;Schook LB;Hu C;Popescu G;Park Y;Ballance WC;Yu S;Im SG;Lee J;Lee CH;Kong H
这种柔软的机器可以拿起和释放一个“活”的细胞片和电子产品，而不会起皱。“活”细胞片或生物电子芯片具有提高诊断和治疗质量的巨大潜力。然而，处理这些薄而精致的材料仍然是一个巨大的挑战，因为用于夹持和释放的外力很容易使材料变形或损坏。这项研究提出了一个软机械手，可以操纵和运输细胞/组织片和可穿戴生物传感设备无缝重演头足类动物的吸盘如何工作。软操纵器由具有组织样柔软性的超快热响应微通道水凝胶层和电加热器层组成。到操纵器的电流驱动凝胶的微通道收缩/膨胀，并导致通过微通道的压力变化。该机械手可以在10秒内提起/分离物体，并可重复使用50次以上。这种软操纵器对于治疗性细胞/组织片和生物传感装置的安全可靠的组装和植入将是非常有用的。
This soft machine can pick up and release an ultrathin “living” cell sheet and electronics without crumpling. “Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.
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影响因子：
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