Measles Edmonston vaccine strain derivatives have potent oncolytic activity against osteosarcoma.
Measles Edmonston vaccine strain derivatives have potent oncolytic activity against osteosarcoma.
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DOI：
10.1038/cgt.2014.54
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发表时间：
2014-11
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
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作者：
Osteosarcoma is the most common primary bone tumor affecting children and young adults, and development of metastatic disease is associated with poor prognosis. The purpose of this study was to evaluate the antitumor efficacy of virotherapy with engineered measles virus (MV) vaccine strains in the treatment of osteosarcoma. Cell lines derived from pediatric patients with osteosarcoma (HOS, MG63, 143B, KHOS-312H, U2-OS and SJSA1) were examined for MV-GFP and MV-NIS gene expression and cytotoxicity as defined by syncytial formation, cell death, and eradication of cell monolayers: significant antitumor activity was demonstrated. Findings were correlated with in vivo efficacy in subcutaneous, orthotopic (tibial bone), and lung metastatic osteosarcoma xenografts treated with the MV derivative MV-NIS via the intratumoral (IT) or intravenous (IV) route. Following treatment, we observed decrease in tumor growth of subcutaneous xenografts (p=0.0374) and prolongation of survival in mice with orthotopic (p<0.0001) and pulmonary metastatic osteosarcoma tumors (p=0.0207). Expression of the NIS transgene in MV-NIS infected tumors allowed for SPECT-CT and PET-CT imaging of virus infected tumors in vivo. Our data support the translational potential of MV-based virotherapy approaches in the treatment of recurrent and metastatic osteosarcoma.
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影响因子：
5.4
作者：
Duprex, WP;McQuaid, S;Rima, BK
通讯作者：
Rima, BK
影响因子：
11.2
作者：
Galanis E;Hartmann LC;Cliby WA;Long HJ;Peethambaram PP;Barrette BA;Kaur JS;Haluska PJ Jr;Aderca I;Zollman PJ;Sloan JA;Keeney G;Atherton PJ;Podratz KC;Dowdy SC;Stanhope CR;Wilson TO;Federspiel MJ;Peng KW;Russell SJ
通讯作者：
Russell SJ
影响因子：
12.4
作者：
Ahn BC
通讯作者：
Ahn BC
DOI：
10.1158/1078-0432.ccr-09-1292
发表时间：
2009-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Mader EK;Maeyama Y;Lin Y;Butler GW;Russell HM;Galanis E;Russell SJ;Dietz AB;Peng KW
通讯作者：
Peng KW
影响因子：
3.6
作者：
Jurianz, K;Ziegler, S;Kirschfink, M
通讯作者：
Kirschfink, M