Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back.
Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back.
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作者：
Ahn BC
分子成像被定义为完整生物体内细胞和亚细胞水平生物过程的视觉表征、表征和量化，可以通过各种成像技术获得，包括核成像方法。正常甲状腺组织和分化型甲状腺癌的成像以及放射性碘治疗甲状腺癌依赖于这些细胞中碘化同调蛋白（NIS）的表达。NIS是一种具有13个跨膜结构域的内在膜蛋白，它将碘从细胞外液中吸收到细胞质中。通过基因转移将NIS的功能转移到不同的细胞中，可以用γ或正电子发射的放射性同位素如Tc-99m、I-123、I-131、I-124和F-18四氟硼酸盐来观察细胞，这些放射性同位素是由NIS积累的。它们也可以用发射β或α的放射性核素处理，如I-131、Re-186、Re-188和At-211，这些放射性核素也是由NIS积累的。本文阐述了NIS作为转运细胞的放射性核素报告基因和治疗癌症的治疗基因在诊断和治疗方面的应用。
Molecular imaging, defined as the visual representation, characterization and quantification of biological processes at the cellular and subcellular levels within intact living organisms, can be obtained by various imaging technologies, including nuclear imaging methods. Imaging of normal thyroid tissue and differentiated thyroid cancer, and treatment of thyroid cancer with radioiodine rely on the expression of the sodium iodide symporter (NIS) in these cells. NIS is an intrinsic membrane protein with 13 transmembrane domains and it takes up iodide into the cytosol from the extracellular fluid. By transferring NIS function to various cells via gene transfer, the cells can be visualized with gamma or positron emitting radioisotopes such as Tc-99m, I-123, I-131, I-124 and F-18 tetrafluoroborate, which are accumulated by NIS. They can also be treated with beta- or alpha-emitting radionuclides, such as I-131, Re-186, Re-188 and At-211, which are also accumulated by NIS. This article demonstrates the diagnostic and therapeutic applications of NIS as a radionuclide-based reporter gene for trafficking cells and a therapeutic gene for treating cancers.
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DOI：
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