Symmetry from Asymmetry or Asymmetry from Symmetry?
Symmetry from Asymmetry or Asymmetry from Symmetry?
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DOI：
10.1101/sqb.2017.82.034272
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Kahney EW;Ranjan R;Gleason RJ;Chen X
DNA复制和有丝分裂的过程允许细胞的遗传信息被可靠地复制和转移到其子细胞。然而，如果DNA复制和细胞分裂总是以对称的方式进行，就会导致肿瘤细胞簇而不是多细胞生物体。因此，要想完全了解任何复杂的生物体，就必须了解细胞如何在忠实地保持相同遗传物质的同时变得不同。众所周知，每种细胞类型中包含的不同表观遗传信息定义了其独特的基因表达程序。然而，亲代细胞中所含的表观遗传信息如何在子代细胞中保持或改变，在很大程度上仍然未知。在果蝇雄性生殖系干细胞（GSCs）的不对称细胞分裂（ACD）过程中，我们的前期工作揭示了已有的组蛋白被选择性地保留在更新的干细胞子细胞中，而新合成的组蛋白则富集在分化的子细胞中。我们还发现，预先存在的组蛋白与新合成的组蛋白的随机遗传导致干细胞丢失和祖生殖细胞肿瘤表型，这表明程序化组蛋白遗传是细胞记忆或重置细胞命运的关键表观遗传参与者。在这里，我们将讨论这些发现的背景下，目前的知识DNA复制，极化有丝分裂机制，ACD为动物发育和组织稳态。我们还将推测一些潜在的机制，不对称组蛋白遗传，这可能是用于其他生物事件，以实现不对称的细胞命运。
The processes of DNA replication and mitosis allow the genetic information of a cell to be copied and transferred reliably to its daughter cells. However, if DNA replication and cell division were always carried out in a symmetric manner, it would result in a cluster of tumor cells instead of a multicellular organism. Therefore, gaining a complete understanding of any complex living organism depends on learning how cells become different while faithfully maintaining the same genetic material. It is well recognized that the distinct epigenetic information contained in each cell type defines its unique gene expression program. Nevertheless, how epigenetic information contained in the parental cell is either maintained or changed in the daughter cells remains largely unknown. During the asymmetric cell division (ACD) of Drosophila male germline stem cells (GSCs), our previous work revealed that preexisting histones are selectively retained in the renewed stem cell daughter, whereas newly synthesized histones are enriched in the differentiating daughter cell. We also found that randomized inheritance of preexisting histones versus newly synthesized histones results in both stem cell loss and progenitor germ cell tumor phenotypes, suggesting that programmed histone inheritance is a key epigenetic player for cells to either remember or reset cell fates. Here we will discuss these findings in the context of current knowledge on DNA replication, polarized mitotic machinery, and ACD for both animal development and tissue homeostasis. We will also speculate on some potential mechanisms underlying asymmetric histone inheritance, which may be used in other biological events to achieve the asymmetric cell fates.
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影响因子：
10.5
作者：
Alabert C;Barth TK;Reverón-Gómez N;Sidoli S;Schmidt A;Jensen ON;Imhof A;Groth A
通讯作者：
Groth A
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
DOI：
10.1007/s10577-013-9358-8
发表时间：
2013-05
期刊：
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
影响因子：
--
作者：
Sauer S;Burkett SS;Lewandoski M;Klar AJ
通讯作者：
Klar AJ
影响因子：
7
作者：
Cayrou, Christelle;Coulombe, Philippe;Mechali, Marcel
通讯作者：
Mechali, Marcel
DOI：
10.1016/j.cub.2009.07.034
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Anderson CT;Stearns T
通讯作者：
Stearns T