You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists.
You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists.
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DOI：
10.1016/j.neuropharm.2012.02.005
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发表时间：
2012-07
影响因子：
4.7
通讯作者：
France CP
中科院分区：
文献类型：
--
作者：
Baladi MG;Daws LC;France CP
多巴胺（DA）在介导摄食行为中的重要作用以及某些药物的正性强化作用已被广泛认识。较少被广泛研究的是喂养条件如何影响作用于DA系统的药物的敏感性。例如，食物限制通常是衰老和长寿研究的重点;然而，其他研究表明，轻度食物限制显着增加对直接和间接作用的DA受体激动剂的敏感性。此外，越来越清楚的是，不仅食物的量，而且食物的类型，是改变药物效果的重要因素。鉴于高脂肪和含糖食物的消费量增加，研究正在探索高可口食物的消费如何影响DA神经化学以及药物对这些系统的影响。例如，吃高脂肪食物会增加对直接作用和间接作用的DA受体激动剂的某些行为效应的敏感性。一个令人信服的机制可能性是，介导某些药物作用的中枢DA途径受到一种或多种内分泌激素（如胰岛素）的调节，这些激素在限食期间或食用高脂肪或含糖食物后发生显著变化。虽然传统上被认为是调节能量稳态的重要信号分子，但胰岛素也可以调节DA神经化学。由于直接和间接作用的DA受体药物用于治疗，有些被滥用，更好地了解食物摄入如何影响对这些药物的反应可能有助于改善临床疾病的治疗，并提供与滥用药物的原因相关的信息。
The important role of dopamine (DA) in mediating feeding behavior and the positive reinforcing effects of some drugs is well recognized. Less widely studied is how feeding conditions might impact the sensitivity of drugs acting on DA systems. Food restriction, for example, has often been the focus of aging and longevity studies; however, other studies have demonstrated that mild food restriction markedly increases sensitivity to direct- and indirect-acting DA receptor agonists. Moreover, it is becoming clear that not only the amount of food, but the type of food, is an important factor in modifying the effects of drugs. Given the increased consumption of high fat and sugary foods, studies are exploring how consumption of highly palatable food impacts DA neurochemistry and the effects of drugs acting on these systems. For example, eating high fat chow increases sensitivity to some behavioral effects of direct- as well as indirect-acting DA receptor agonists. A compelling mechanistic possibility is that the central DA pathways that mediate the effects of some drugs are regulated by one or more of the endocrine hormones (e.g. insulin) that undergo marked changes during food restriction or after consuming high fat or sugary foods. Although traditionally recognized as an important signaling molecule in regulating energy homeostasis, insulin can also regulate DA neurochemistry. Because direct- and indirect-acting DA receptor drugs are used therapeutically and some are abused, a better understanding of how food intake impacts response to these drugs would likely facilitate improved treatment of clinical disorders and provide information that would be relevant to the causes of vulnerability to abuse drugs.
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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