Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice.
Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice.
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DOI：
10.1159/000356144
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发表时间：
2014
影响因子：
2.4
通讯作者：
Woods JA
中科院分区：
文献类型：
--
作者：
Martin SA;Dantzer R;Kelley KW;Woods JA
脂多糖（LPS）对先天免疫系统的外周刺激导致老年小鼠长期的抑郁样行为，这依赖于吲哚胺2，3双加氧酶（IDO）的激活。有规律的中等强度运动训练已被证明具有神经保护作用，可能会减少老年小鼠的抑郁样行为。本研究的目的是检验自愿轮跑会减弱LPS诱导的抑郁样行为和脑IDO基因表达的假设，在4个月和22个月大的C57 BL/6 J小鼠。将小鼠用转轮（Voluntary Wheel Running，VWR）或无转轮（Standard）饲养30天（年轻成年小鼠）或70天（老年小鼠），之后腹膜内注射LPS（年轻成年小鼠：0.83 mg/kg;老年小鼠：0.33 mg/kg）。年轻的成年VWR小鼠平均每天跑6.9公里，而老年VWR小鼠平均每天跑3.4公里。与其各自的标准对照组相比，年轻成年和老年VWR小鼠的强迫运动耐量均增加。VWR对年轻成年或老年小鼠中脂多糖诱导的厌食症、体重减轻、悬尾试验中不动性增加以及蔗糖偏好降低均无影响。注射LPS后4小时（年轻成年小鼠）和24小时（老年小鼠），TNF-α、IL-1β、IL-6和IDO的转录物在全脑中上调，与VWR无关。这些结果表明，长时间的体育锻炼对LPS的神经炎症反应及其行为后果没有影响。
Peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes prolonged depressive-like behavior in aged mice that is dependent on indoleamine 2,3 dioxygenase (IDO) activation. Regular moderate intensity exercise training has been shown to exert neuroprotective effects that might reduce depressive-like behavior in aged mice. The purpose of this study was to test the hypothesis that voluntary wheel running would attenuate LPS-induced depressive-like behavior and brain IDO gene expression in 4-month-old and 22-month-old C57BL/6J mice. Mice were housed with a running wheel (Voluntary Wheel Running, VWR) or no wheel (Standard) for 30 days (young adult mice) or 70 days (aged mice), after which they were intraperitoneally injected with LPS (young adult mice: 0.83 mg/kg; aged mice: 0.33 mg/kg). Young adult VWR mice ran on average 6.9 km/day, while aged VWR mice ran on average 3.4 km/day. Both young adult and aged VWR mice increased their forced exercise tolerance compared to their respective Standard control groups. VWR had no effect on LPS-induced anorexia, weight-loss, increased immobility in the tail suspension test, and decreased sucrose preference in either young adult or aged mice. Four (young adult mice) and twenty-four (aged mice) hours after injection of LPS transcripts for TNF-α, IL-1β, IL-6, and IDO were upregulated in the whole brain independently of VWR. These results indicate that prolonged physical exercise has no effect on the neuroinflammatory response to LPS and its behavioral consequences.
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影响因子：
15.1
作者：
Kohman, Rachel A.;DeYoung, Erin K.;Bhattacharya, Tushar K.;Peterson, Lindsey N.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.
影响因子：
2.7
作者：
Duman, Catharine H.;Schlesinger, Lee;Terwilliger, Rosemarie;Russell, David S.;Newton, Samuel S.;Duman, Ronald S.
通讯作者：
Duman, Ronald S.
影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
通讯作者：
Gemma, Carmelina
DOI：
10.1523/jneurosci.5818-10.2011
发表时间：
2011-03-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cortese GP;Barrientos RM;Maier SF;Patterson SL
通讯作者：
Patterson SL
影响因子：
--
作者：
Beekman, ATF;Geerlings, SW;van Tilburg, W
通讯作者：
van Tilburg, W