Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers.
Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers.
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DOI：
10.3389/fendo.2022.843539
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发表时间：
2022
影响因子：
5.2
通讯作者：
Celi FS
中科院分区：
文献类型：
--
作者：
Chen S;Wohlford GF;Vecchie' A;Carbone S;Yavuz S;Van Tassell B;Abbate A;Celi FS
碘塞罗宁的药代动力学引起心血管毒性的担忧。虽然血清T3浓度持续升高的影响已得到充分描述，但由于甲状腺激素的快速作用，T3浓度急性变化的影响知之甚少。探讨T3水平一过性升高对心血管系统和能量代谢的临床意义。双盲、三组、安慰剂对照、交叉研究（ClinicalTrials.gov标识符：NCT 03098433）。12名志愿者（3名女性，9名男性），年龄27.7 ± 5.1岁。在3次相同的研究访视中口服碘甲状腺原氨酸0.7 mcg/kg、等摩尔剂量的左甲状腺素（0.86 mcg/kg）或安慰剂。在时间0 '、60'、120'、180'、240 '采集用于总T3、游离T4的血样。使用容量钳夹法连续记录心率、血压和血流动力学数据。用间接量热法测定静息能量消耗。每次研究访视时，在基线和末次采血后进行超声心动图检查。心血管功能和能量消耗的变化。碘塞洛宁给药后，血清T3达到Cmax 421 ± 57 ng/dL，估计Tmax为120 ± 26分钟。在心率、血压、血流动力学参数、能量消耗和超声心动图参数方面，未观察到研究组之间的差异。高剂量碘甲状腺原氨酸对心血管系统没有可测量的快速作用，这支持了进行长期研究以评估其在甲状腺功能减退症患者中的安全性和有效性的基本原理。
The pharmacokinetics of liothyronine causes concerns for cardiovascular toxicity. While the effects of sustained increase in serum T3 concentrations are well described, little is known on the effects of acute changes in T3 concentrations due to rapid action of thyroid hormone. To assess the clinical relevance of transient increase of T3 levels on cardiovascular system and energy metabolism. Double-blind, three arms, placebo controlled, cross-over study (ClinicalTrials.gov Identifier: NCT03098433). Twelve volunteers (3 females, 9 males), age 27.7 ± 5.1 years. Oral administration of liothyronine 0.7 mcg/kg, equimolar dose of levothyroxine (0.86 mcg/kg), or placebo in three identical study visits. Blood samples for total T3, free T4 were collected at times 0’, 60’ 120’ 180’ 240’. Continuous recording of heart rate, blood pressure, and hemodynamic data was performed using the volume clamp method. Resting energy expenditure was measured by indirect calorimetry. An echocardiogram was performed on each study visit at baseline and after the last blood sampling. Changes in cardiovascular function and energy expenditure. Following the administration of liothyronine, serum T3 reached a Cmax of 421 ± 57 ng/dL with an estimated Tmax of 120 ± 26 minutes. No differences between study arms were observed in heart rate, blood pressure, hemodynamics parameters, energy expenditure, and in echocardiogram parameters. The absence of measurable rapid effects on the cardiovascular system following a high dose of liothyronine supports the rationale to perform long-term studies to assess its safety and effectiveness in patients affected by hypothyroidism.
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影响因子：
3.8
作者：
Trankle, Cory;Canada, Justin M.;Abbate, Antonio
通讯作者：
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作者：
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