Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease.
Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease.
复制标题
DOI：
10.1111/ene.13797
复制
发表时间：
2019-03
影响因子：
5.1
通讯作者：
McMillan CT
中科院分区：
文献类型：
--
作者：
Chahine LM;Dos Santos C;Fullard M;Scordia C;Weintraub D;Erus G;Rosenthal L;Davatzikos C;McMillan CT
帕金森病（PD）中的痴呆是常见的和致残的。确定可改变的风险因素至关重要。血管危险因素可能与早期PD的认知能力下降有关。需要作为血管危险因素对PD长期影响的替代物的生物标志物。为此，我们的目的是量化早期PD中的白色高信号，测量与血管危险因素的相关性，并检查白色高信号与纵向认知之间的关系。帕金森进展标志物倡议研究的参与者（141名PD患者，63名健康对照）具有足够的基线结构脑MRI。合并高血压和糖尿病史以及体重指数，以创建血管风险评分。通过自动化方法定量白色高信号。认知能力每年进行一次综合测试。在PD组中，血管风险评分与全脑（β=0.210;p=0.021）、全白色（β=0.214;p=0.013）、额叶（β=0.220;p=0.002）和颞叶（β=0.212;p=0.002）区域的白色高信号相关。总体认知的年变化率在血管风险评分较高（β=-0.040;p=0.007）和白色高信号较高（β=-0.029;p=0.049）的患者中更大。较高的时间白色高强度负荷与言语记忆随时间的大幅下降相关（β=-0.034;p=0.031）。在早期PD中，可改变的血管危险因素与脑MRI上的白色高信号相关。时间性白色物质高强度负荷预测言语记忆下降。白色高信号可作为血管危险因素对PD患者认知能力影响的替代指标。
Dementia in Parkinson’s disease (PD) is common and disabling. Identification of modifiable risk factors for it is essential. Vascular risk factors may be associated with cognitive decline in early PD. Biomarkers that serve as surrogates of the long-term effect of vascular risk factors on PD are needed. To that end, we aimed to quantitate white matter hyperintensities in early PD, measure associations with vascular risk factors, and examine relationships between white matter hyperintensities and longitudinal cognition. Participants in the Parkinson Progression Markers Initiative study (141 PD patients, 63 healthy controls) with adequate baseline structural brain MRIs were included. Hypertension and diabetes history, and body mass index, were combined to create a vascular risk score. White matter hyperintensities were quantitated via automated methods. Cognition was assessed annually with a comprehensive test battery. In the PD group, vascular risk score was associated with white matter hyperintensities for total brain (β=0.210;p=0.021), total white matter (β=0.214;p=0.013), frontal (β=0.220;p=0.002) and temporal (β=0.212;p=0.002) regions. Annual rate of change in global cognition was greater in those with higher vascular risk score (β=−0.040;p=0.007) and greater white matter hyperintensities (β=−0.029;p=0.049). Higher temporal white matter hyperintensity burden was associated with great decline over time in verbal memory (β=−0.034;p=0.031). In early PD, modifiable vascular risk factors are associated with white matter hyperintensities on brain MRI. Temporal white matter hyperintensity burden predicts decline in verbal memory. White matter hyperintensities may serve as a surrogate marker for the effect of vascular risk factors on cognitive abilities in PD.
登录
查看更多内容
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
--
作者：
BENTON, AL;VARNEY, NR;HAMSHER, KD
通讯作者：
HAMSHER, KD
DOI：
10.1155/2014/507529
发表时间：
2014
期刊：
Parkinson's disease
影响因子：
--
作者：
Jones JD;Jacobson C;Murphy M;Price C;Okun MS;Bowers D
通讯作者：
Bowers D
影响因子：
5.7
作者：
Doshi J;Erus G;Ou Y;Resnick SM;Gur RC;Gur RE;Satterthwaite TD;Furth S;Davatzikos C;Alzheimer's Neuroimaging Initiative
通讯作者：
Alzheimer's Neuroimaging Initiative
影响因子：
8.6
作者：
Malek, Naveed;Lawton, Michael A.;Swallow, Diane M. A.;Grosset, Katherine A.;Marrinan, Sarah L.;Bajaj, Nin;Barker, Roger A.;Burn, David J.;Hardy, John;Morris, Huw R.;Williams, Nigel M.;Wood, Nicholas;Ben-Shlomo, Yoav;Grosset, Donald G.
通讯作者：
Grosset, Donald G.