Influence of hypertension on neurocognitive domains in nondemented Parkinson's disease patients.
Influence of hypertension on neurocognitive domains in nondemented Parkinson's disease patients.
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DOI：
10.1155/2014/507529
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bowers D
中科院分区：
文献类型：
--
作者：
Jones JD;Jacobson C;Murphy M;Price C;Okun MS;Bowers D
目标。众所周知，健康并存，特别是心血管危险因素，会对老年人的认知能力下降构成风险。到目前为止，很少有人关注这些并发症对帕金森病(PD)的影响。这项研究考察了除了疾病严重程度的影响外，共病对PD患者认知状态的影响及其患病率。方法：研究方法。采用横断面设计，包括341例无严重认知功能减退的PD患者的神经心理学数据。通过查阅病历收集共病数据。使用一系列多层次回归分析数据，控制与PD相关的疾病变量。结果。总体样本特征是69%的男性，疾病持续时间9.7年，统一帕金森病分级量表26.4岁，年龄64.7岁。高胆固醇血症(41.6%)、高血压(38.1%)和低血压(30.2%)是最常见的合并症。高血压的存在对执行功能和言语记忆领域有显著贡献。立位性低血压的并存缓和了高血压与执行功能之间的关系。结论。这项对大量帕金森病患者的研究提供了健康并存，特别是高血压对认知领域的有害影响的证据，这些认知领域传统上被概念化为额叶和/或时间中介。
Objective. Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults. To date, little attention has focused on the impact of these comorbidities on Parkinson's disease (PD). This study examined the prevalence and contribution of comorbidities on cognitive status in PD patients, above and beyond the effects of disease severity. Methods. A cross sectional design was used, including neuropsychological data on 341 PD patients without severe cognitive decline. Comorbidity data were collected via medical chart review. Data were analyzed using a series of multiple hierarchical regressions, controlling for PD-related disease variables. Results. Overall sample characteristics are 69% male, disease duration 9.7 years, Unified Parkinson's Disease Rating Scale 26.4, and age 64.7 years. Hypercholesterolemia (41.6%), hypertension (38.1%), and hypotension (30.2%) were the most reported comorbidities. The presence of hypertension significantly contributed to domains of executive function and verbal memory. The cooccurrence of orthostatic hypotension moderated the relationship between hypertension and executive function. Conclusions. This study on a large cohort of PD patients provides evidence for a detrimental influence of health comorbidities, particularly hypertension, on cognitive domains that have traditionally been conceptualized as being frontally and/or temporally mediated.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
9.9
作者：
Aarsland, D;Andersen, K;Kragh-Sorensen, P
通讯作者：
Kragh-Sorensen, P
影响因子：
5.7
作者：
Rose, Kathryn M.;Couper, David;Gottesman, Rebecca F.
通讯作者：
Gottesman, Rebecca F.
影响因子：
4.2
作者：
Saxby, BK;Harrington, F;Ford, GA
通讯作者：
Ford, GA