Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
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异种生物生物代谢基因多态性和卵巢癌风险。
DOI：
10.1002/mc.20714
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发表时间：
2011-05
影响因子：
4.6
通讯作者：
Sellers, Thomas A.
中科院分区：
文献类型：
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作者：
Goode, Ellen L.;White, Kristin L.;Vierkant, Robert A.;Phelan, Catherine M.;Cunningham, Julie M.;Schildkraut, Joellen M.;Berchuck, Andrew;Larson, Melissa C.;Fridley, Brooke L.;Olson, Janet E.;Webb, Penelope M.;Chen, Xiaoqing;Beesley, Jonathan;Chenevix-Trench, Georgia;Sellers, Thomas A.
由于选择的外源性代谢酶处理致癌物，可以启动卵巢癌的发生，我们假设，编码外源性代谢酶的基因中的单核苷酸多态性（SNP）与卵巢癌的风险。来自三项研究的浸润性上皮性卵巢癌病例（N = 1，571，包括956例浆液性亚型）和对照组（N = 2，046）在EPHX 1，ADH 4，ADH 1A，NQO 2，NAT 2，GST P1，CYP 1A 1和NQO 1的11个SNP进行基因分型，随后在一个参与者子集中进行初始SNP筛查。通过Illumina GoldenGate和Sequenom iPlex技术获得的基因型的Logistic回归分析揭示了以下年龄和研究调整的关联：EPHX 1 rs 1051740与浆液性卵巢癌风险增加（每等位基因比值比（OR）1.17，95%置信区间（95% CI）1.04-1.32，p = 0.01），ADH 4 r1042364与卵巢癌风险降低（OR 0.90，95% CI 0.81-1.00，p = 0.05），NQO 1 rs 291766与卵巢癌风险增加（OR 1.11，95% CI 1.00-1.23，p = 0.04）。这些发现与先前的研究结果一致，这些基因与致癌作用有关，并表明这些变异体值得在其他研究中进行随访。
Because selected xenobiotic-metabolizing enzymes process pro-carcinogens that could initiate ovarian carcinogenesis, we hypothesized that single-nucleotide polymorphisms (SNPs) in the genes encoding xenobiotic-metabolizing enzymes are associated with risk of ovarian cancer. Cases with invasive epithelial ovarian cancer (N = 1,571 including 956 of serous sub-type) and controls (N = 2,046) from three studies were genotyped at 11 SNPs in EPHX1, ADH4, ADH1A, NQO2, NAT2, GSTP1, CYP1A1, and NQO1, following an initial SNP screen in a subset of participants. Logistic regression analysis of genotypes obtained via Illumina GoldenGate and Sequenom iPlex technologies revealed the following age- and study-adjusted associations: EPHX1 rs1051740 with increased serous ovarian cancer risk (per-allele odds ratio (OR) 1.17, 95% confidence interval (95% CI) 1.04–1.32, p = 0.01), ADH4 r1042364 with decreased ovarian cancer risk (OR 0.90, 95% CI 0.81–1.00, p = 0.05), and NQO1 rs291766 with increased ovarian cancer risk (OR 1.11, 95% CI 1.00–1.23, p = 0.04). These findings are consistent with prior studies implicating these genes in carcinogenesis and suggest that this collection of variants is worthy of follow-up in additional studies.
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DOI：
10.1158/1055-9965.epi-07-2849
发表时间：
2008-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
Cunningham JM;Sellers TA;Schildkraut JM;Fredericksen ZS;Vierkant RA;Kelemen LE;Gadre M;Phelan CM;Huang Y;Meyer JG;Pankratz VS;Goode EL
通讯作者：
Goode EL
影响因子：
11.5
作者：
Goode, Ellen L.;Maurer, Matthew J.;Hartmann, Lynn C.
通讯作者：
Hartmann, Lynn C.
影响因子：
3.5
作者：
HASSETT, C;AICHER, L;OMIECINSKI, CJ
通讯作者：
OMIECINSKI, CJ
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
30.8
作者：
通讯作者：
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