Variability in interval production is due to timing-dependent deficits in Huntington's disease.
Variability in interval production is due to timing-dependent deficits in Huntington's disease.
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DOI：
10.1002/mds.25998
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发表时间：
2014-10
影响因子：
8.6
通讯作者：
Rakitin, Brian C.
中科院分区：
文献类型：
--
作者：
Rao, Ashwini K.;Marder, Karen S.;Uddin, Jasim;Rakitin, Brian C.
在亨廷顿舞蹈病 (HD) 中，需要隐式控制时间的运动任务的表现存在更大的变异性。我们检查了在显式间隔定时任务中定时可变性是否也很明显。 60 名受试者（21 名对照组、19 名明显 HD 和 20 名预明显 HD）执行了具有三个目标间隔（1.1 秒、2.2 秒、3.3 秒）的单一间隔制作任务。我们分析了各组和区间的准确性（比例误差）和精度（标准差）。不同组或不同时间间隔的准确性没有差异。与对照组相比，显性 HD (p=0.0001) 和预显 HD (p=0.04) 的精确度显着降低。对于接近诊断（基于五年内诊断的概率）的表现前受试者尤其如此。精确度与诊断的接近程度相关（r2=0.3，p<0.01）。为了检查精度降低的根源，我们进行了标准差与间隔持续时间的线性回归。与对照组和远离诊断的显性 HD 参与者相比，显性 HD (p=0.02) 和显性 HD 接近诊断 (p=0.04) 的回归斜率显着更高。在亨廷顿病的临床诊断之前，计时精度会受到损害。斜率分析表明，时序可变性（精度降低）是由于时序相关过程的缺陷造成的。我们的结果为基底神经节参与中央计时功能的提议提供了额外的支持。由于单间隔生产任务对预表现 HD 的缺陷很敏感，因此时间精度可能是未来临床试验中有用的结果衡量标准。
In Huntington’s disease (HD) increased variability is seen in performance of motor tasks that require implicit control of timing. We examined if timing variability was also evident in an explicit interval-timing task. Sixty subjects (21 controls, 19 manifest HD and 20 pre-manifest HD) performed a single interval production task with three target intervals (1.1s, 2.2s, 3.3s). We analyzed accuracy (proportional error) and precision (standard deviation) across groups and intervals. No differences were seen in accuracy across groups or intervals. Precision was significantly lower in manifest (p=0.0001) and pre-manifest HD (p=0.04) compared with controls. This was particularly true for pre-manifest subjects close to diagnosis (based on probability of diagnosis in five years). Precision was correlated with proximity to diagnosis (r2=0.3, p<0.01). To examine the source of reduced precision, we conducted linear regression of standard deviation with interval duration. Slope of the regression was significantly higher in manifest HD (p=0.02) and in pre-manifest HD close to diagnosis (p=0.04) compared with controls and pre-manifest participants far from diagnosis. Timing precision is impaired before clinical diagnosis in Huntington’s disease. Slope analysis suggests that timing variability (decreased precision) was due to deficits in timing dependent processes. Our results provide additional support for the proposal that the basal ganglia are implicated in central timekeeping functions. Since the single interval production task was sensitive to deficits in pre-manifest HD, temporal precision may be a useful outcome measure in future clinical trials.
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DOI：
10.1037/0096-1523.21.1.3
发表时间：
1995-02-01
影响因子：
2.1
作者：
IVRY, RB;HAZELTINE, RE
通讯作者：
HAZELTINE, RE
影响因子：
8.6
作者：
Rao, Ashwini K.;Muratori, Lisa;Marder, Karen S.
通讯作者：
Marder, Karen S.
影响因子：
3.5
作者：
Langbehn, DR;Brinkman, RR;Hayden, MR
通讯作者：
Hayden, MR
影响因子：
2.5
作者：
Rakitin, BC;Stern, Y;Malapani, C
通讯作者：
Malapani, C
影响因子：
3.2
作者：
Rakitin, BC;Scarmeas, N;Stern, Y
通讯作者：
Stern, Y