Trans-kingdom cross-talk: small RNAs on the move.
Trans-kingdom cross-talk: small RNAs on the move.
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DOI：
10.1371/journal.pgen.1004602
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发表时间：
2014-09
期刊：
影响因子：
4.5
通讯作者：
Thordal-Christensen H
中科院分区：
文献类型：
--
作者：
Knip M;Constantin ME;Thordal-Christensen H
本文从跨王国基因沉默的角度对小RNA(SRNA)分子的迁移性进行了综述。SRNA分子在生物体内的流动是一种众所周知的现象，促进了细胞和组织之间的基因沉默。SRNA信号也在同一物种和不同物种的生物体之间传递。值得注意的是，近年来描述了许多发生在不同王国的生物体之间的RNA信号交换的例子。这些例子主要存在于宿主与病原体、寄生虫和共生体之间的相互作用中。然而，它们可能只代表了冰山一角，因为新出现的图片表明，生物生态位中的生物通常会交换RNA沉默信号。在这种情况下，我们需要充分考虑这一点，以理解给定的生物平衡是如何获得的。尽管观察到了许多跨王国的RNA信号传递，但这些信号的几个机制方面仍然不清楚。然而，这种RNA信号转移已经被用于实际目的。病原体基因可以被植物产生的影响这些基因的sRNA沉默。这也被称为宿主诱导基因沉默(HIGS)，它有可能成为未来重要的疾病控制方法。
This review focuses on the mobility of small RNA (sRNA) molecules from the perspective of trans-kingdom gene silencing. Mobility of sRNA molecules within organisms is a well-known phenomenon, facilitating gene silencing between cells and tissues. sRNA signals are also transmitted between organisms of the same species and of different species. Remarkably, in recent years many examples of RNA-signal exchange have been described to occur between organisms of different kingdoms. These examples are predominantly found in interactions between hosts and their pathogens, parasites, and symbionts. However, they may only represent the tip of the iceberg, since the emerging picture suggests that organisms in biological niches commonly exchange RNA-silencing signals. In this case, we need to take this into account fully to understand how a given biological equilibrium is obtained. Despite many observations of trans-kingdom RNA signal transfer, several mechanistic aspects of these signals remain unknown. Such RNA signal transfer is already being exploited for practical purposes, though. Pathogen genes can be silenced by plant-produced sRNAs designed to affect these genes. This is also known as Host-Induced Genes Silencing (HIGS), and it has the potential to become an important disease-control method in the future.
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DOI：
10.1038/nrg3355
发表时间：
2013-02
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.4
作者：
An, QL;Hückelhoven, R;Van Bel, AJE
通讯作者：
Van Bel, AJE
DOI：
10.1073/pnas.0706701104
发表时间：
2007-09-11
影响因子：
11.1
作者：
Brosnan, C. A.;Mitter, N.;Carroll, B. J.
通讯作者：
Carroll, B. J.
影响因子：
10.5
作者：
Chang SS;Zhang Z;Liu Y
通讯作者：
Liu Y
影响因子：
21.3
作者：
Lee, Young Sik;Pressman, Sigal;Andress, Arlise P.;Kim, Kevin;White, Jamie L.;Cassidy, Justin J.;Li, Xin;Lubell, Kim;Lim, Do Hwan;Cho, Ik Sang;Nakahara, Kenji;Preall, Jonathan B.;Bellare, Priya;Sontheimer, Erik J.;Carthew, Richard W.
通讯作者：
Carthew, Richard W.